Results 161 to 170 of about 1,034,896 (346)

Effects of acute adolescent stress on the acquisition and maintenance of intravenous oxycodone self-administration in male and female rats. [PDF]

Drug Alcohol Depend
Gallagher CA, Chandler DJ, Manvich DF.
europepmc   +1 more source

A Dual‐Responsive Versatile Nanohybrid Orchestrating Tumor Elimination and Tumor‐Associated Osteolysis Restoration via Sequential Release

Advanced Science, EarlyView.
The versatile CaO2@CuMOF@HAP nanohybrid demonstrates an outstanding MMP9/pH‐triggered release performance for sequential release of osteogenic growth peptide into deep‐seated tumor‐infiltrated bone destruction areas and dual ions into tumor cells, enabling efficient tumor‐associated osteolysis restoration and tumor elimination for more comprehensive ...
Lan Liu, Han‐Zhe Liu, Zhe‐Nan Liu, Tong Wang, Li‐Li Yu, Qiu‐Jing Li, Zi‐Yi Chen, Guo‐Feng Luo, Zheng‐Jun Shang   +8 more
wiley   +1 more source

Introducing personalized patient care in overactive bladder management using the MedRing OAB system for intravaginal oxybutynin administration. [PDF]

Drug Deliv
Peltenburg SI, Koopmans I, Heerema-Snoep O, Klaassen ES, Juachon MJ, Otten A, Klarenbeek NB.   +6 more
europepmc   +1 more source

NK Cell Activation by Platinum Boosts Immunotherapy in HR+/HER2− Breast Cancer

Advanced Science, EarlyView.
Multi‐omics and single‐cell analyses identify activated NK cells as key mediators of anti‐PD‐(L)1 response in HR+/HER2− breast cancer. Platinum chemotherapy enhances NK cell cytotoxicity through NF‐κB–associated signaling, synergizing with immunotherapy and providing a rationale for combination treatment.
Yi‐Yu Chen, Yi‐Fan Zhou, Xuan Qi, Ya‐Xin Zhao, Tong Fu, Xi Jin, Minhong Shen, Yi‐Zhou Jiang, Zhi‐Ming Shao   +8 more
wiley   +1 more source

Real-world data on the abuse potential of medications for the treatment of insomnia: a disproportionality analysis of the FAERS database. [PDF]

Front Pharmacol
Saskin P, McCall WV, Neubauer DN, Crucitti A, Perry B, Luyet PP, Jaziri R, Vaillant C.   +7 more
europepmc   +1 more source

Oxycodone self-administration in male and female rats

Psychopharmacology, 2017
M. Mavrikaki, Marco Pravetoni, Sarah Page, David N. Potter, E. Chartoff   +4 more
semanticscholar   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

A Bayesian pharmacokinetics integrated phase I-II design to optimize dose-schedule regimes. [PDF]

Biostatistics
Lu M, Yuan Y, Liu S.
europepmc   +1 more source

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

Advanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang, Mingfu Gong, Tao Sun, Shilin Xiao, Yue Zhao, Xiaofeng Yang, Wansu Zhang, Chunyu Zhou, Xu Liu, Dong Zhang   +9 more
wiley   +1 more source

Sex, social rank, and nicotine co-administration shape cocaine- and cocaethylene-induced reinstatement in monkeys. [PDF]

Front Behav Neurosci
Roberts BF, Clark MA, Nader MA, Rough MI.   +3 more
europepmc   +1 more source