Results 161 to 170 of about 144,045 (218)
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Fixed-interval schedules for drug self-administration in the rat
Psychopharmacology, 1989The practicality of using second-order fixed-interval schedules in studies of heroin reinforcement with rats was examined. Optimum rates of responding were obtained with a dose of 0.03 mg/kg/infusion and an interval duration of 3 min. In addition, schedules consisting of a only a single interval were shown to be practical, leading to response rates ...
W A, Corrigall, K M, Coen
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Drug Self-Administration by Laboratory Animals: Control by Schedules of Reinforcement
Annual Review of Pharmacology and Toxicology, 1978A common factor underlying all concepts of drug dependence is the persistent maintenance of behavior that leads to drug self-administration (I, 2). Early studies of drug self-administration by laboratory animals involved morphine and employed subjects that were made physiologically (physically) dependent by repeated injec tions prior to the initiation
R D, Spealman, S R, Goldberg
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Second-order schedules of intravenous drug self-administration in rhesus monkeys
Pharmacology Biochemistry and Behavior, 1977Lever-pressing behavior was generated and maintained in 3 rhesus monkeys by intravenous infusions of morphine or cocaine under a second-order schedule of reinforcement. Under this schedule, every tenth lever-press response (FR 10) during a fixed interval of time produced a 2 sec stimulus light.
J R, Sanchez-Ramos, C R, Schuster
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Progressive-ratio schedules of drug delivery in the analysis of drug self-administration: a review
Psychopharmacology, 1998Drugs, like other reinforcers, can vary in their relative abilities to support operant responding. Considerable research has been designed to obtain useful measures of a given drug's or dose's "reinforcing efficacy" and to identify the ways in which a variety of behavioral and pharmacological variables impact these measures. Progressive-ratio schedules
D, Stafford, M G, LeSage, J R, Glowa
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Effects of drugs on schedule-controlled behavior in rats during chronic haloperidol administration.
The Journal of Pharmacology and Experimental Therapeutics, 1985Dose-response curves for haloperidol, phencyclidine, morphine, meperidine and cimetidine were determined in rats trained under a multiple fixed-ratio 30, fixed-interval 5-min schedule of reinforcement. Haloperidol, morphine, meperidine and cimetidine decreased both fixed-ratio and fixed-interval rates of responding.
S K, Rastogi, D E, McMillan
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Journal of Neuroscience Methods, 1996
Drug self-administration studies have recently employed progressive ratio (PR) schedules to examine psychostimulant and opiate reinforcement. This review addresses the technical, statistical, and theoretical issues related to the use of the PR schedule in self-administration studies in rats.
N R, Richardson, D C, Roberts
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Drug self-administration studies have recently employed progressive ratio (PR) schedules to examine psychostimulant and opiate reinforcement. This review addresses the technical, statistical, and theoretical issues related to the use of the PR schedule in self-administration studies in rats.
N R, Richardson, D C, Roberts
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Psychopharmacology, 1998
The studies presented here were designed to further clarify the nature of nicotine self-administration (SA) based on a limited access model in which rats are food restricted, receive operant training using food reinforcement, and are then tested in daily 1-h drug sessions.
E C, Donny +5 more
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The studies presented here were designed to further clarify the nature of nicotine self-administration (SA) based on a limited access model in which rats are food restricted, receive operant training using food reinforcement, and are then tested in daily 1-h drug sessions.
E C, Donny +5 more
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Schedule-induced drug self-administration
1993Publisher Summary This chapter describes schedule-induced drug self-administration. The characteristics of schedule-induced behavior bear some similarities to the behavioral features of drug abuse. Both are chronically excessive sorts of behavior with powerful motivational efficacies.
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[Drug administration schedules in geriatric patients].
Medicina clinica, 1992In this study the prescription of drugs in an outpatients geriatric population was evaluated in terms of age and body weight.From a wide survey carried out on 500 geriatric outpatients, all the prescriptions corresponding to H-2 antagonists, digoxin, theophylline, bromazepam, diazepam, lorazepam and triazolam were analyzed. The patients studied were of
M L, Lucena González +5 more
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Естественные и технические науки, 2020
В данной статье рассматриваются результаты исследования по использованию гормональных препаратов в определённом режиме с целью контроля и управления репродуктивными функциями млекопитающих при искусственном осеменении на примере кроликов. The article discusses the results of hormonal drugs ...
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В данной статье рассматриваются результаты исследования по использованию гормональных препаратов в определённом режиме с целью контроля и управления репродуктивными функциями млекопитающих при искусственном осеменении на примере кроликов. The article discusses the results of hormonal drugs ...
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