Results 171 to 180 of about 144,045 (218)

Low-dose (5 mg/kg) desferrioxamine treatment in acutely aluminium-intoxicated haemodialysis patients using two drug administration schedules

Nephrology Dialysis Transplantation, 1996
According to the recommendations proposed at The Consensus Conference on Diagnosis and Treatment of Aluminium Overload in End-Stage Renal Failure Patients, Paris, 1992 low-dose desferrioxamine (DFO) treatment was applied for the first time in 41 acutely aluminium-intoxicated patients.DFO-related neurological/ophthalmological side-effects were observed ...
Barata, J.D., d' Haese, Patrick C., Pires, C., Lamberts, L.V., Simoes, J., de Broe, Marc E.   +5 more
openaire   +3 more sources

The Influence of Dose Schedules and Administration Routes on the Toxicity of Potential Antiviral Drugs

1984
The influence of two differently constructed dose schedules and of two dissimilar administration routes on the subacute toxicity of the potential antiviral drug benzoxazolyl-2-formyl-S-ethyl-isothiosemicarbazone was investigated in mice. Administration of identical aliquots of the, route dependent, maximally tolerated, dose was found to cause no ...
R, Amlacher, H, Hoffmann
openaire   +2 more sources

Pre-exposure of rats to amphetamine sensitizes self-administration of this drug under a progressive ratio schedule

Psychopharmacology, 1998
Two groups of male rats were tested to determine whether pre-exposure to d-amphetamine would enhance the motivation to self-administer the drug under a progressive ratio schedule of reinforcement. In the first phase of the experiment, one group of rats received d-amphetamine (2 mg/kg IP), while a second group received saline on alternate days for a ...
A, Mendrek, C D, Blaha, A G, Phillips
openaire   +2 more sources

Measures of cocaine-seeking behavior using a multiple schedule of food and drug self-administration in rats

Drug and Alcohol Dependence, 1995
Animal models of human drug abuse measuring (i) cocaine-seeking behavior maintained by primary or secondary reinforcers, (ii) the time to extinction of cocaine-seeking behavior, and (iii) following extinction, reinstatement of operant responding resulting in presentation of a cocaine-associated stimulus were developed in rats.
R, Weissenborn, M, Yackey, G F, Koob, F, Weiss   +3 more
openaire   +2 more sources

Defining the Optimal Schedule of Drug Administration: Art or Science?

Journal of Clinical Oncology, 2008
The optimal use of the oral fluoropyrimidine carbamate capecitabine (Xeloda; Hoffman-Roche, Nutley, NJ) has been the subject of much debate, with empirical exploration of both doses and schedules different from those approved. In the current issue of the Journal, Traina et al describe a phase I trial of a 7-day capecitabine schedule derived rationally ...
openaire   +1 more source

Clinical Efficacy, Extrapyramidal Symptoms and Serum Levels: Influence of Administration Schedules and Concomitant Drugs on Serum Bromperidol Concentrations

Psychiatry and Clinical Neurosciences, 1984
Abstract: Bromperidol (4 or 12 mg per day) was administered to 18 newly admitted schizophrenics and 29 chronic schizophrenic inpatients once or four times a day and the two dose schedules were compared. The bromperidol levels in the four‐times‐a‐day group were significantly higher than those in the once‐a‐day group and the daily variation in the serum
Y, Fujii, M, Tateyama, M, Kamisada, A, Tanoue, M, Takamiya, S, Nakajima, H, Itoh   +6 more
openaire   +2 more sources

[Developing a dose-administration schedule for drug therapy in childhood].

Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1983
For the application of a target concentration strategy for the assessment of dosage regimens pharmacokinetic parameters and their variances must be known. Since pharmacokinetic parameters like the elimination constant or the volume of distribution undergo considerable changes during the perinatal period until early childhood, the application of ...
O, Richter, D, Reinhardt, W, Stutzinger
openaire   +1 more source

Abuse liability of the anesthetic propofol: self-administration of propofol in rats under fixed-ratio schedules of drug delivery

Psychopharmacology, 2000
Previous reports suggest that propofol (PPF) may have abuse potential in humans. Hence, we hypothesized that PPF could reinforce self-administration behavior in other species. Positive reinforcing effects of PPF could be interpreted as an index of abuse liability.Acquisition and maintenance of i.v.
M G, LeSage, D, Stafford, J R, Glowa
openaire   +2 more sources

[Irinotecan: various administration schedules, study of drug combinations, phase I experience].

Bulletin du cancer, 1999
Irinotecan (CPT11) is a synthetic camptothecin-derived DNA topoisomerase I inhibitor. Based on phase I clinical trials, several schedules have been recommended for phase I studies including 350 mg/m2 every 3 weeks in Europe, 125 mg/m2 for 4 weeks every 6 weeks in the USA, and 100 mg/m2 weekly or delayed until recovery in case of grade > 2 toxicity in ...
V, Boige, E, Raymond, J P, Armand
openaire   +1 more source

[Therapeutic results in malignant lymphomas treated by the COPP and POPP drug administration schedules].

Voprosy onkologii, 1981
The paper deals with a comparison of the results of treatment of 19 patients with malignant lymphomas, mostly diffuse ones, stage 3, by POPP schedule (paphencyl, vincristine (oncovine), procarbosin (natulan) and prednisolone) and 37 similar patients who received a modified standard COPP treatment.
L I, Iavorkovskiĭ, A Ia, Rotsena, O Iu, Udris, R Ia, Bliumental', M A, Zile   +4 more
openaire   +1 more source