Results 71 to 80 of about 490,902 (326)

Trends in co-prescribed opioids and benzodiazepines, non-prescribed opioids and benzodiazepines, and schedule-I drugs in the United States, 2013 to 2019

Preventive Medicine Reports
Concurrent opioid and benzodiazepine users are at increased risk of overdose death, compared to opioid-only users. The objective of this study was to understand recent time trends in opioid and benzodiazepine concurrent use, misuse, and schedule-I drug ...
Shaden A. Taha, Jordan R. Westra, Danyel H. Tacker, Mukaila A. Raji, Yong-Fang Kuo   +4 more
doaj   +1 more source

Individual differences in delay discounting and nicotine self-administration in rats [PDF]

, 2009
Delay discounting—a behavioral measure of impulsivity defined as a tendency to prefer a small, immediate reward over a larger reward delayed in time—has been extensively linked with tobacco smoking.
Sweitzer, Maggie M.
core  

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Carbon disulfide mediates socially-acquired nicotine self-administration. [PDF]

PLoS ONE, 2014
The social environment plays a critical role in smoking initiation as well as relapse. We previously reported that rats acquired nicotine self-administration with an olfactogustatory cue only when another rat consuming the same cue was present during ...
Tengfei Wang, Hao Chen
doaj   +1 more source

Oral Administration of Levo-Tetrahydropalmatine Attenuates Reinstatement of Extinguished Cocaine Seeking by Cocaine, Stress or Drug-Associated Cues in Rats [PDF]

, 2011
Cocaine addiction is characterized by a persistently heightened susceptibility to drug relapse. For this reason, the identification of medications that prevent drug relapse is a critical goal of drug abuse research.
Baker, David A., Bohr, Colin, Figueroa-Guzman, Yazmin, Graf, Evan N., Li, Shi-Jiang, Mantsch, John R., Mueller, Christopher R, Vranjkovic, Oliver, Wisniewski, Samantha, Yang, Zheng   +9 more
core   +2 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Patterns of non-adherence to oral antiretroviral medication: frequencies of consecutively missed doses

Patient Preference and Adherence, 2019
Anna S Kaufman, Alan Morrison ScribCo, Effort, PA, USA Purpose: The therapeutic effect of a once-daily oral drug will be maintained if there are no occurrences of consecutively missed doses that exceed the duration of the drug’s effect.
Kaufman AS, Morrison A
doaj  

Adherence and feasibility of 2 treatment schedules of S-1 as adjuvant chemotherapy for patients with completely resected advanced lung cancer: a multicenter randomized controlled trial

BMC Cancer, 2017
Background We conducted a multicenter randomized study of adjuvant S-1 administration schedules for surgically treated pathological stage IB-IIIA non-small cell lung cancer patients.
Yoshinobu Hata, Takaharu Kiribayashi, Kazuma Kishi, Makoto Nagashima, Takefumi Nakayama, Shingo Ikeda, Mitsutaka Kadokura, Yuichi Ozeki, Hajime Otsuka, Yoshitaka Murakami, Keigo Takagi, Akira Iyoda   +11 more
doaj   +1 more source

Transcranial direct current stimulation (tDCS) reduces motivation to drink ethanol and reacquisition of ethanol self-administration in female mice

Scientific Reports, 2022
Transcranial direct current stimulation (tDCS) is an emerging noninvasive brain neuromodulation technique aimed at relieving symptoms associated with psychiatric disorders, including addiction.
Solène Pedron, Stéphanie Dumontoy, Maria del Carmen González-Marín, Fabien Coune, Andries Van Schuerbeek, Emmanuel Haffen, Mickael Naassila, Vincent Van Waes   +7 more
doaj   +1 more source

Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction [PDF]

, 2016
The nociceptin (NOP) receptor is a G-protein-coupled receptor whose natural ligand is the nociceptin/orphanin FQ (N/OFQ) peptide. Evidence from pharmacological studies suggests that the N/OFQ system is implicated in the regulation of several addiction ...
A Kuzmin, A Post, A Rizzi, A Rizzi, AC Hansson, B Spagnolo, C Mollereau, D Economidou, D Economidou, D Economidou, EC Gavioli, F Jenck, FM Dautzenberg, Friedbert Weiss, G de Guglielmo, G de Guglielmo, GC Sartor, Giordano de Guglielmo, Girolamo Calò, Giulia Scuppa, H Aujla, H Zhang, J Huang, J Kotlinska, JA Briant, JC Meunier, JM Witkin, JR Homberg, JR Walker, K Rutten, K Rutten, K Sakoori, K Sakoori, K Sakoori, Linda M Rorick-Kehn, LM Rorick-Kehn, M Corbani, M Kallupi, M Kallupi, MA Statnick, MA Toledo, Marsida Kallupi, Michael A Statnick, NR Richardson, NT Zaveri, P Marquez, P Marquez, R Ciccocioppo, R Ciccocioppo, R Ciccocioppo, R Ciccocioppo, R Ciccocioppo, RJ Zhao, RK Reinscheid, RL Pennock, Roberto Ciccocioppo, S Semenova, S Spampinato, T Darland, VA Holanda, X Xuei   +60 more
core   +2 more sources