Results 281 to 290 of about 4,150,951 (316)

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai   +8 more
wiley   +1 more source

Animal models of cisplatin‐induced neuropathic pain

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This article illustrates the modeling process of a cisplatin‐induced neuropathic pain model in rats or mice. Multiple modeling tests are required for rats or mice before, during, and after modeling. The appropriate injection method, dose, and modeling method are selected, and multiple assays are chosen for evaluation and comparison.
Ningxin Li   +9 more
wiley   +1 more source

Nanoallergen platform for detection of platin drug allergies

open access: bronze, 2019
Peter E. Deak   +6 more
openalex   +1 more source

Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang   +5 more
wiley   +1 more source

Harnessing the multidimensional bioactivity of Chaetomorpha aerea: Integrative phytochemical profiling with in vitro, in vivo, and in silico insights

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This study revealed the antioxidant, anti‐inflammatory, and antidiabetic potentials of the seaweed Chaetomortpha aerea using in vitro, in vivo, and in silico approaches along with phytochemical analysis using gas chromatography–mass spectrometry. ADME/T analysis was also carried out to confirm drug likeness and toxicity prediction.
Md. Mahmudul Hasan   +7 more
wiley   +1 more source

Advances on Albumin‐Based Carriers for Anticancer Drug Delivery

open access: yesAdvanced NanoBiomed Research, EarlyView.
This study systematically classifies the drug delivery modes of albumin by examining the characteristics of its surface‐active groups and internal binding sites. It provides an in‐depth analysis of various drug delivery strategies and their corresponding targeting mechanisms.
Ruoli Zhou   +4 more
wiley   +1 more source

Nanoparticles Functionalized with Polymer Brushes for Gene Delivery

open access: yesAdvanced NanoBiomed Research, EarlyView.
The engineering of the next generation gene delivery vectors requires the precise control of the architecture and physicochemical interactions controlling the transport, targeting, uptake, and release of nucleic acid materials to targeted cells. Polymer brush‐functionalized nanomaterials offer unprecedented control over such design and properties, and ...
Carlos E. Neri‐Cruz, Julien E. Gautrot
wiley   +1 more source

Physicochemical Stability and Sensory Evaluation of Novel Fish Oil Fortified Plant Milk Beverages

open access: yesJournal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Omega‐3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are imperative for general biological functions and may be involved in the prevention and treatment of various diseases. Despite the benefits, US consumption of fish, and consequently EPA and DHA, is below recommended levels.
Abigail A. Sommer, Yael Vodovotz
wiley   +1 more source

Advances in Chlorinated Polyethylene: Properties, Applications, and Future Directions

open access: yesJournal of Applied Polymer Science, EarlyView.
This work highlights recent advances in the synthesis of chlorinated polyethylene (CPE), its versatile industrial applications, and emerging innovations driving its future development in sustainable materials. ABSTRACT Elastomeric chlorinated polyethylene (CM or E‐CPE) integrates the thermoplastic's dynamic processing properties with the elastomer's ...
J. I. Mnyango   +7 more
wiley   +1 more source

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