Results 161 to 170 of about 2,834,658 (290)

Novel therapeutic strategies for ccRCC through integration of systemic drug combinations and oncolytic adenovirus immunotherapy. [PDF]

Front Immunol
Feodoroff M, Mogollon I, Hamdan F, Luck TJ, Kumari R, Bottega P, Sandberg J, Romppanen E, Paavolainen L, Malmstedt M, Penttilä P, Kallioniemi O, Mirtti T, Rannikko A, Grönholm M, Cerullo V, Pietiäinen V.   +16 more
europepmc   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Corrigendum: Differential effects of clopidogrel and/or aspirin on the healing of tooth extraction wound bone tissue

Frontiers in Physiology
Jiaping Wang, Juan Lin, Xin Song, Mengting Wang, Yan Chen, Ning Luo, Xin Wu   +6 more
doaj   +1 more source

A structure-based modeling approach identifies effective drug combinations for RAS-mutant acute myeloid leukemia. [PDF]

iScience
Jones L, Rukhlenko O, Dias T, Imoto H, Carmody C, Wynne K, Kholodenko BN, Bond J.   +7 more
europepmc   +1 more source

Drug interactions and lethal drug combinations [PDF]

Journal of Clinical Pathology, 1975
openaire   +3 more sources

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Systematic modeling predicts synergistic and safe drug combinations for parasitic diseases. [PDF]

PLoS Negl Trop Dis
Su Y, Zhang H, Du Y, Li L, Lv G, Jiang H.   +5 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Breaking Through the Limits: Nanomedicine at the Service of New Drug Combinations to Tackle Pancreatic Cancer. [PDF]

Wiley Interdiscip Rev Nanomed Nanobiotechnol
Bincoletto V, Andreana I, Stella B, Modjtahedi N, Arpicco S, Urbinati G.   +5 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source