Results 191 to 200 of about 737,831 (320)

Drug Combinations Targeting FAK and MEK Overcomes Tumor Heterogeneity in Glioblastoma. [PDF]

Pharmaceutics
Furqan M, Elliott RJR, Nagle PWK, Dawson JC, Masalmeh R, Garcia VA, Munro AF, Drake C, Morrison GM, Pollard SM, Ebner D, Brunton VG, Frame MC, Carragher NO.   +13 more
europepmc   +1 more source

Development of drug resistance in patients receiving combinations of zidovudine, didanosine and nevirapine

, 2001
Brian Conway, Mark A. Wainberg, David B. Hall, Marianne Harris, Peter Reiss, David A. Cooper, Stefano Vella, R. L. Curry, Patrick Robinson, Joep M. A. Lange, Julio Montaner   +10 more
openalex   +1 more source

Effect of drug combinations on admission for recurrent myocardial infarction [PDF]

, 2007
Menno E. van der Elst, Marcel L. Bouvy, C. J. De Blaey, A. de Boer   +3 more
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Flash optimization of drug combinations for Acinetobacter baumannii with IDentif.AI-AMR. [PDF]

NPJ Antimicrob Resist
You K, Binte Mohamed Yazid N, Chong LM, Hooi L, Wang P, Zhuang I, Chua S, Lim E, Kok AZX, Marimuthu K, Vasoo S, Ng OT, Chan CEZ, Chow EK, Ho D.   +14 more
europepmc   +1 more source

Predicting anticancer synergistic drug combinations based on multi-task learning. [PDF]

BMC Bioinformatics, 2023
Chen D, Wang X, Zhu H, Jiang Y, Li Y, Liu Q, Liu Q.   +6 more
europepmc   +1 more source

The Efficacy of Potent Anti-retroviral Drug Combinations Tested in a Murine Model of HIV-1 Encephalitis

, 2001
Jenae Limoges, Larisa Y. Poluektova, Winai Ratanasuwan, Jennifer Rasmussen, Marina Zelivyanskaya, Daniel McClernon, E. Randall Lanier, Howard E. Gendelman, Yuri Persidsky   +8 more
openalex   +1 more source

Melarsoprol-Free Drug Combinations for Second-Stage Gambian Sleeping Sickness: The Way to Go. [PDF]

, 2007
Balasegaram, Brun, F. Chappuis, Priotto, P  pin, P  pin, Van Nieuwenhove   +6 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [PDF]

Cell Rep Methods, 2023
Bertin P, Rector-Brooks J, Sharma D, Gaudelet T, Anighoro A, Gross T, Martínez-Peña F, Tang EL, Suraj MS, Regep C, Hayter JBR, Korablyov M, Valiante N, van der Sloot A, Tyers M, Roberts CES, Bronstein MM, Lairson LL, Taylor-King JP, Bengio Y.   +19 more
europepmc   +1 more source