Results 191 to 200 of about 398,363 (249)

Hemorrhage Risk Associated with Anticoagulant and Antiplatelet Drug Combinations: Insights from the USFDA Adverse Event Reporting System. [PDF]

J Clin Med
Sridharan K, Sivaramakrishnan G.
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

BOP2-Comb: Bayesian Optimal Phase II Design for Optimizing Doses and Assessing Contribution of Components in Drug Combinations. [PDF]

Ther Innov Regul Sci
Chi X, Yuan Y, Lin R.
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Estimating the treatment effects of multiple drug combinations on multiple outcomes in hypertension. [PDF]

Cell Rep Med
Liu R, Li L, Zhang P.
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Cancer Cell's Achilles Heels: Considerations for Design of Anti-Cancer Drug Combinations. [PDF]

Int J Mol Sci
Gahramanov V, Vizeacoumar FS, Morales AM, Bonham K, Sakharkar MK, Kumar S, Vizeacoumar FJ, Freywald A, Sherman MY.   +8 more
europepmc   +1 more source

The association of prescriber prominence in a shared-patient physician network with their patients receipt of and transitions between risky drug combinations. [PDF]

Appl Netw Sci
O'Malley AJ, Meara E, Morden NE, Moen EL, Ran X.   +4 more
europepmc   +1 more source

A new method for concomitant evaluation of drug combinations for their antimicrobial properties. [PDF]

MethodsX
Rizvi SA, Chowdhury KF, Borsetto C, Travis ER, Saif M, Ahmed V, Carter LJ, Ahmad I, McNally A, Haq QMR.   +9 more
europepmc   +1 more source

Comparison of cilomilast, tadalafil, and both drug combinations in the treatment of monocrotaline-induced pulmonary arterial hypertension in rats. [PDF]

BMC Cardiovasc Disord
Ermis N, Ozhan O, Yıldız A, Ulutas Z, Parlakpinar H, Ulu A, Ates B, Vardi N, Kucukakcali Z, Acet A.   +9 more
europepmc   +1 more source