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Drug–drug combinations revisited
European Journal of Hospital Pharmacy, 2013The use of fixed-dose combinations (FDCs) in the daily practice of pharmacotherapy is increasing after years in the shadows. The main reasons for this renewed popularity are the increasing number of drugs prescribed per patient and the complexity of current pharmacotherapy.
Bjerrum, Ole Jannik +3 more
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Multiple Sclerosis Journal, 1996
As a result of recent therapeutic trials, recombinant Interferon beta (r/FNβ)-1b and-1a as well as Copolymer 1 (COP 1) and to some extent unspecific immunosuppressants have been accepted as partially efficient treatments of relapsing-remitting MS. In view of partially effective single treatments, the question arises if combination of two or even more ...
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As a result of recent therapeutic trials, recombinant Interferon beta (r/FNβ)-1b and-1a as well as Copolymer 1 (COP 1) and to some extent unspecific immunosuppressants have been accepted as partially efficient treatments of relapsing-remitting MS. In view of partially effective single treatments, the question arises if combination of two or even more ...
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Combination of Antiarrhythmic Drugs
Journal of Cardiovascular Pharmacology, 1991Antiarrhythmic treatment with single agents is often ineffective and can be limited by dose-dependent side effects. Therefore, combinations of antiarrhythmic drugs in smaller and well-tolerated doses are advocated in cases refractory to single antiarrhythmic drugs.
Ralph Mletzko +3 more
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Combination of Antiretroviral Drugs as Microbicides
Current HIV Research, 2012Tenofovir, a highly prescribed drug for the treatment of HIV/AIDS infections, has recently also shown its effectiveness as a potential topical microbicide drug in the prevention of HIV transmission. Here, we discuss the combination of tenofovir with various other antiretrovirals (ARV) highlighting the large class of carbohydrate-binding agents (CBAs ...
Dominique Schols, Jan Balzarini
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Challenges of drug combinations [PDF]
Science, 2020 Antibiotic Resistance Combinations of antibiotics are used to treat intractable infections such as methicillin-resistant Staphylococcus aureus . Clinically, however, drugs tend to be used empirically, and results can be contradictory. Liu et al. translated observations made in vitro to patient samples to understand the role of antibiotic tolerance in ...
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Drug Treatment of Combined Hyperlipidemia
American Journal of Cardiovascular Drugs, 2001Combined hyperlipidemia is increasing in frequency and is the most common lipid disorder associated with obesity, insulin resistance and diabetes mellitus. It is associated with other features of the metabolic syndrome including hypertension, hyperuricemia, hyperinsulinemia and highly atherogenic subfractions of lipoprotein remnant particles including ...
Wierzbicki, A S +2 more
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Rationale for drug combinations
European Journal of Cancer, 2003No reader of this journal needs to be reminded that real progress in the treatment of solid tumours is hard to achieve. The explosion of scientific knowledge about the metabolism of tumours and the genetic influences that promote or restrict growth will it is hoped lead to the more rationale design of therapeutics, which in future will be more ...
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2013
Antimicrobial combination therapy has a long history. The potential for synergy between two antimicrobial agents has been sought using in vitro techniques such as disk approximation, checkerboard titration, in vitro killing experiments with fixed drug concentrations, through the use of in vitro pharmacodynamic models, through animal models, and through
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Antimicrobial combination therapy has a long history. The potential for synergy between two antimicrobial agents has been sought using in vitro techniques such as disk approximation, checkerboard titration, in vitro killing experiments with fixed drug concentrations, through the use of in vitro pharmacodynamic models, through animal models, and through
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Combination drug therapy for combined hyperlipidemia
Current Cardiology Reports, 1999Combination therapy for hyperlipidemia, especially combined hyperlipidemia, may have advantages over single drug therapy, affording better improvement in lipoprotein risk factors and possibly better prevention of atherothrombotic events. Although preliminary experience has been gained using treatment combinations of niacin with statins, and fibrates ...
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Drug Combinations in Pain Management
Journal Of Pain & Palliative Care Pharmacotherapy, 2006Combinations of two or more drugs in analgesic regimens are described. Clinical implications of such combinations are discussed.
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