Results 71 to 80 of about 943,135 (348)

Clinical development of new drug-radiotherapy combinations. [PDF]

, 2016
In countries with the best cancer outcomes, approximately 60% of patients receive radiotherapy as part of their treatment, which is one of the most cost-effective cancer treatments.
Adams, RA, Ataman, O, Baird, RD, Billingham, L, Brown, SR, Buckland, S, Bulbeck, H, Chalmers, AJ, Clack, G, Clay, R, Cranston, AN, Damstrup, L, Ferraldeschi, R, Forster, MD, Golec, J, Greenhalgh, TA, Hagan, RM, Hall, E, Hanauske, AR, Harrington, KJ, Haswell, T, Hawkins, MA, Illidge, T, Jones, H, Kelly, S, Kennedy, AS, McDonald, F, Melcher, T, NCRI CTRad Academia-Pharma Joint Working Group, O'Connor, JP, Plummer, R, Pollard, JR, Saunders, MP, Sebag-Montefiore, D, Sharma, RA, Smitt, M, Staffurth, J, Stock, JK, Stratford, IJ, Wedge, SR   +39 more
core   +8 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Identification and Tracking of Antiviral Drug Combinations

Viruses, 2020
Combination therapies have become a standard for the treatment for HIV and hepatitis C virus (HCV) infections. They are advantageous over monotherapies due to better efficacy, reduced toxicity, as well as the ability to prevent the development of ...
Aleksandr Ianevski, Rouan Yao, Svetlana Biza, Eva Zusinaite, Andres Mannik, Gaily Kivi, Anu Planken, Kristiina Kurg, Eva-Maria Tombak, Mart Ustav, Nastassia Shtaida, Evgeny Kulesskiy, Eunji Jo, Jaewon Yang, Hilde Lysvand, Kirsti Løseth, Valentyn Oksenych, Per Arne Aas, Tanel Tenson, Astra Vitkauskienė, Marc P. Windisch, Mona Høysæter Fenstad, Svein Arne Nordbø, Mart Ustav, Magnar Bjørås, Denis E. Kainov   +25 more
doaj   +1 more source

Graph-augmented Convolutional Networks on Drug-Drug Interactions Prediction [PDF]

, 2019
We propose an end-to-end model to predict drug-drug interactions (DDIs) by employing graph-augmented convolutional networks. And this is implemented by combining graph CNN with an attentive pooling network to extract structural relations between drug pairs and make DDI predictions. The experiment results suggest a desirable performance achieving ROC at
arxiv   +1 more source

DDI Prediction via Heterogeneous Graph Attention Networks [PDF]

arXiv, 2022
Polypharmacy, defined as the use of multiple drugs together, is a standard treatment method, especially for severe and chronic diseases. However, using multiple drugs together may cause interactions between drugs. Drug-drug interaction (DDI) is the activity that occurs when the impact of one drug changes when combined with another.
arxiv  

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

PHARMACOECONOMIC ANALYSIS OF ANTIHYPERTENSIVE DRUG COMBINATIONS USE

Рациональная фармакотерапия в кардиологии, 2015
Aim. To pursue pharmacoeconomic analysis of two drug combinations of ACE inhibitor (enalapril) and diuretic.Material and methods. Patients with arterial hypertension degree 2 and diabetes mellitus type 2 without ischemic heart disease (n=56) were ...
E. I. Tarlovskaya, Y. A. Balandina, N. S. Maximchuk-Kolobova   +2 more
doaj   +3 more sources

Mechanism-Independent Method for Predicting Response to Multidrug Combinations in Bacteria [PDF]

, 2014
Drugs are commonly used in combinations larger than two for treating bacterial infection. However, it is generally impossible to infer directly from the effects of individual drugs the net effect of a multidrug combination.
Cluzel, Philippe, Nishida, Satoshi, Sontag, Eduardo D., Wood, Kevin   +3 more
core   +1 more source

Study of Combinatorial Drug Synergy of Novel Acridone Derivatives With Temozolomide Using in-silico and in-vitro Methods in the Treatment of Drug-Resistant Glioma

Frontiers in Oncology, 2021
Drug resistance is one of the critical challenges faced in the treatment of Glioma. There are only limited drugs available in the treatment of Glioma and among them Temozolomide (TMZ) has shown some effectiveness in treating Glioma patients, however, the
Malobika Chakravarty, Piyali Ganguli, Piyali Ganguli, Manikanta Murahari, Ram Rup Sarkar, Ram Rup Sarkar, Godefridus Johannes Peters, Godefridus Johannes Peters, Y. C. Mayur   +8 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source