Results 71 to 80 of about 419,272 (285)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Three drug combinations for late-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Uganda.

, 2006
OBJECTIVES: Our objective was to compare the efficacy and safety of three drug combinations for the treatment of late-stage human African trypanosomiasis caused by Trypanosoma brucei gambiense.
Louga, Albino, Fogg Carole, Louga Albino, Ghabri, S, Piola, P, Piola, Patrice, Balasegaram, M, Checchi Francesco, Balasegaram, Manica, Priotto Gerardo, Louga, A, Checchi, F, Priotto, Gerardo, Priotto, G, Erphas, Olema, Checchi, Francesco, Ghabri, Salah, Erphas, O, Balasegaram Manica, Ghabri Salah, Erphas Olema, Fogg, C, Fogg, Carole, Piola Patrice   +23 more
core   +1 more source

Clinical relevance of drug-drug interactions : a structured assessment procedure. [PDF]

, 2005
Item does not contain fulltextINTRODUCTION: Computerised drug interaction surveillance systems (CIS) may be helpful in detecting clinically significant drug interactions. Experience with CIS reveals that they often yield alerts with questionable clinical
Flikweert, S., Langendijk, PNJ, Smits, P, le Comte, M., Brouwers, J.R.B.J., van Roon, EN; id_orcid, Roon, E.N. van, Langendijk, P.N., Kwee-Zuiderdijk, W.J.M., Brouwers, JRBJ, Flikweert, S, van Roon, E.N., van Roon, EN, Comte, M. le, le Comte, M, Kwee-Zuiderwijk, WJM, Smits, P., Kwee-Zuiderwijk, W.J., Langendijk, P.J.N.   +18 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Observed frequencies (reporting probabilities) table for drug-drug-AE combinations.

Observed frequencies (reporting probabilities) table for drug-drug-AE combinations.
Inkyung Jung (94394), Dagyeom Jung (18397199)   +1 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Prediction of drug combinations by integrating molecular and pharmacological data. [PDF]

, 2011
Combinatorial therapy is a promising strategy for combating complex disorders due to improved efficacy and reduced side effects. However, screening new drug combinations exhaustively is impractical considering all possible combinations between drugs ...
Michael Kuhn, Murat Iskar, Iskar, M., Zhao, X.M., Georg Zeller, Zeller, G., Vera van Noort, van Noort, V., Bork, P., Peer Bork, Kuhn, M., Xing-Ming Zhao   +11 more
core   +1 more source

Optimal doses of five drug combinations.

, 2021
Optimal doses of five drug combinations.
Andrew G. Edwards (5938214), Wayne R. Giles (3359036), Karoline Horgmo Jæger (6785450), Aslak Tveito (6785453)   +3 more
core   +1 more source

Synergistic Effects of Artesunate in Combination with Amphotericin B and Miltefosine against Leishmania infantum: Potential for Dose Reduction and Enhanced Therapeutic Strategies

Antibiotics
Leishmaniasis is a tropical infectious disease caused by Leishmania parasites. The disease can be spread by the bite of an infected sand fly. Currently, five chemotherapeutic drugs are available in leishmaniasis treatment.
Nuchpicha Intakhan, Atiporn Saeung, Sonia M. Rodrigues Oliveira, Maria de Lourdes Pereira, Wetpisit Chanmol   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source