Results 251 to 260 of about 27,194 (296)

Definition of Drug-Likeness for Compound Affinity

Journal of Chemical Information and Modeling, 2011
We proposed a new definition of drug-likeness based on protein-compound docking simulation. Active and decoy compounds of 40 target proteins were investigated. These compounds were docked to protein sets consisting of 53-160 proteins. The protein sets did not include the target proteins.
Yoshifumi Fukunishi, Haruki Nakamura
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Risks of Compounded Drugs

JAMA Internal Medicine, 2014
A nurse notices “floaters” in an infusion bag of magnesium sulfate, initiatingachainofdiscoveries that causesasinglehospital to recall 12 000unitsof44 typesofproducts sourced from thesamecompoundingpharmacy. In this issue, Boyce et al1 describe how this drug quality problem, which was eventually identified as fungal contamination, led to the ...
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Neurogenic Drugs and Compounds

Recent Patents on CNS Drug Discovery, 2010
The advent of adult neurogenesis and neural stem cell (NSC) research opens new avenues and opportunities for treating neurological diseases and disorders, particularly for the discovery and development of novel drugs. Adult neurogenesis is modulated by a broad range of stimuli, physio- and pathological processes, trophic factors/cytokines and drugs ...
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Drug Compounding, Drug Safety, and the First Amendment

Hastings Center Report, 2013
AbstractIn September 2012, news broke of a developing drug disaster in the United States. Health authorities had linked a fungal meningitis outbreak to a contaminated steroid made by a company called the New England Compounding Center. The contaminated steroid was a compounded drug that had not been approved by the Food and Drug Administration ...
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Compounding and filling: drug substance to drug product

2012
Brian K. Meyer, Louis Coless
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Compound names for drugs

Drug and Therapeutics Bulletin, 1970
As the number of presentations of drugs, both alone and in combination increases it becomes more difficult to provide suitable names. Some names are double-barrelled whilst others have a number or letter prefix or suffix. Such prefixes or suffixes vary greatly in their origin and meaning, are not normally part of official drug names, and often confuse ...
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Selection Criteria for Drug‐Like Compounds

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
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Virtual Compound Screening In Drug Discovery

Future Medicinal Chemistry, 2012
Virtual screening (VS) methods are applied in both academia and drug discovery, and can be divided into ligand- and target structure-based approaches. The VS field is still evolving and is characterized by scientific heterogeneity. The value of virtual compound screening for drug discovery is often debated, in particular, given the large investments ...
Dagmar, Stumpfe, Peter, Ripphausen, Jürgen, Bajorath   +2 more
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Compounding of Veterinary Drugs for Equine Practitioners

Veterinary Clinics of North America: Equine Practice, 2017
Equine practitioners should follow these recommendations when using compounded medications: (1) the decision must be veterinary driven, based on a valid veterinarian-client-patient relationship and on evidence-based medicine; (2) compliance with the Animal Medicinal Drug Use Clarification Act of 1994; and (3) use limited to (a) horses for which no ...
Scott D, Stanley, Krysta, Moffitt, Valerie, Wiebe   +2 more
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Natural Endoperoxides as Drug Lead Compounds

Current Medicinal Chemistry, 2016
Natural products, especially bioactive molecules as drug lead compounds, have attracted extensive attention in health promotion and in drug discovery and development. It is essential to understand the structures and functional mechanisms of these lead molecules prior to drug development.
Ming, Bu, Burton B, Yang, Liming, Hu
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