Results 311 to 320 of about 79,448 (358)

Compounding Intrathecal Drugs

2009
Publisher Summary This chapter focuses on various issues related to the compounding of intrathecal drugs. For the majority of practitioners who use intrathecal drugs for chronic pain management, compounding represents the only mechanism to obtain the drugs and drug combinations necessary for some of their patients.
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Piperazine compounds as drugs of abuse

Drug and Alcohol Dependence, 2012
Synthetic drugs are among the most commonly abused drugs in the world. This abuse is widespread among young people, especially in the dance club and rave scenes. Over the last several years, piperazine derived drugs have appeared, mainly available via the internet, and sold as ecstasy pills or under the names of "Frenzy", "Bliss", "Charge", "Herbal ...
M D, Arbo, M L, Bastos, H F, Carmo
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Natural Endoperoxides as Drug Lead Compounds

Current Medicinal Chemistry, 2016
Natural products, especially bioactive molecules as drug lead compounds, have attracted extensive attention in health promotion and in drug discovery and development. It is essential to understand the structures and functional mechanisms of these lead molecules prior to drug development.
Ming, Bu, Burton B, Yang, Liming, Hu
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Diving for drugs: tunicate anticancer compounds

Drug Discovery Today, 2012
The marine biosphere boasts tremendous biodiversity replete with structurally unique, active and selective secondary metabolites. Bioprospecting for antitumor compounds has been rewarding, and tunicates have been especially successful in yielding prospective cancer therapies.
Edwin L, Cooper, David, Yao
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Drug to Genome to Drug: Discovery of New Antiplasmodial Compounds

Journal of Medicinal Chemistry, 2011
The dominant strategy for discovery of new antimalarial drugs relies on cell-free assays on specific biochemical pathways of Plasmodium falciparum . However, it appears that screening directly on the parasite is a more rewarding approach. The "drug to genome to drug" approach consists of testing a small set of structural analogues of a drug acting on ...
Beghyn, Terence B., Charton, Julie, Leroux, Florence, Laconde, Guillaume, Bourin, Arnaud, Cos, Paul, Maes, Louis, Deprez, Benoit   +7 more
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Compound Immobilization and Drug-Affinity Chromatography

2011
Bioactive small molecules act through modulating a yet unpredictable number of targets. It is therefore of critical importance to define the cellular target proteins of a compound as an entry point to understanding its mechanism of action. Often, this can be achieved in a direct fashion by chemical proteomics.
Uwe, Rix, Manuela, Gridling, Giulio, Superti-Furga   +2 more
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Natural Compounds as Drugs

2008
Activation of fungal silent gene clusters: A new avenue to drug discovery.- Total synthesis studies on macrocyclic pipecolic acid natural products: FK506, the antascomicins and rapamycin.- Application of natural product-inspired diversity-oriented synthesis to drug discovery.- Cheminformatics analysis of natural products: Lessons from nature inspiring ...
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Compound Data Mining for Drug Discovery

2016
In recent years, there has been unprecedented growth in compound activity data in the public domain. These compound data provide an indispensable resource for drug discovery in academic environments as well as in the pharmaceutical industry. To handle large volumes of heterogeneous and complex compound data and extract discovery-relevant knowledge from
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TRPs: Modulation by Drug-Like Compounds

2014
Drug-like compounds that exert biological activity towards TRP channels are either being used as cell biological tools or further developed into pharmacological lead structures aiming at therapeutic use in diseased states. Although drug-likeliness is not easy to predict, common rules include a relatively low molecular weight, physicochemical ...
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Prediction of Transporter-Mediated Drug–Drug Interactions Using Endogenous Compounds

Clinical Pharmacology & Therapeutics, 2012
Therapy with two or more drugs is more the rule than the exception, particularly in aging societies. Drug-drug interactions are frequently undesirable and may lead to increased toxicity and mortality. Inhibition of transporters is one major mechanism underlying drug-drug interactions.
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