Results 1 to 10 of about 594,889 (120)

Milk-derived exosomes exhibit versatile effects for improved oral drug delivery

Acta Pharmaceutica Sinica B, 2022
As endogenous courier vesicles, exosomes play crucial roles in macromolecule transmission and intercellular communication. Therefore, exosomes have drawn increasing attention as biomimetic drug-delivery vehicles over the past few years.
Lei Wu, Lingling Wang, Xi Liu, Yuli Bai, Ruinan Wu, Xiang Li, Yutong Mao, Ling Zhang, Yongxiang Zheng, Tao Gong, Zhirong Zhang, Yuan Huang   +11 more
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Formation of Aggregate-Free Gold Nanoparticles in the Cyclodextrin-Tetrachloroaurate System Follows Finke–Watzky Kinetics

Nanomaterials, 2022
Cyclodextrin-capped gold nanoparticles are promising drug-delivery vehicles, but the technique of their preparation without trace amounts of aggregates is still lacking, and the size-manipulation possibility is very limited.
Yuri Sergeyevich Pestovsky, Teerapol Srichana   +1 more
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Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode

Drug Delivery, 2023
Recently, various novel drug delivery systems have been developed to overcome ocular barriers in order to improve drug efficacy. We have previously reported that montmorillonite (MT) microspheres (MPs) and solid lipid nanoparticles (SLNs) loaded with the
Huamei Li, Fuda Dai, Hanyu Liu, Qi Tao, Jie Hu, Yangrong Zhang, Zhenping Xiao, Ilva D. Rupenthal, Huihui Li, Fan Yang, Wei Li, Huaqing Lin, Dongzhi Hou   +12 more
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Nose-to-brain delivery of temozolomide-loaded PLGA nanoparticles functionalized with anti-EPHA3 for glioblastoma targeting

Drug Delivery, 2018
Glioblastoma is the most common malignant brain tumor. Efficient delivery of drugs targeting glioblastomas remains a challenge. Ephrin type-A receptor 3 (EPHA3) tyrosine kinase antibody-modified polylactide-co-glycolide (PLGA) nanoparticles (NPs) were ...
Liuxiang Chu, Aiping Wang, Ling Ni, Xiuju Yan, Yina Song, Mingyu Zhao, Kaoxiang Sun, Hongjie Mu, Sha Liu, Zimei Wu, Chunyan Zhang   +10 more
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Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer’s Disease

Research, 2023
Inflammatory responses, manifested in excessive oxidative stress and microglia overactivation, together with metal ion-triggered amyloid-beta (Aβ) deposition, are critical hallmarks of Alzheimer’s disease (AD).
Qianqian Huang, Chaoqing Jiang, Xue Xia, Yufan Wang, Chenxing Yan, Xiaorong Wang, Ting Lei, Xiaotong Yang, Wenqin Yang, Guo Cheng, Huile Gao   +10 more
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Synthesis, Characterization, and Evaluation of Redox-Sensitive Chitosan Oligosaccharide Nanoparticles Coated with Phycocyanin for Drug Delivery

Nanoscale Research Letters, 2019
In this paper, a type of phycocyanin (PC)-functionalized and curcumin (CUR)-loaded biotin-chitosan oligosaccharide-dithiodipropionic acid-curcumin (BCSC) nanoparticles, called CUR-BCSC@PCs, were designed to enhance the biocompatibility of CUR.
Ziting Cheng, Wei Zhang, Xiaoya Hou, Bingjie Wang, Yanping Zhu, Peng Zhang, Feng Zhao, Daquan Chen   +7 more
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Pharmacological Characterization of Toludesvenlafaxine as a Triple Reuptake Inhibitor

Frontiers in Pharmacology, 2021
Toludesvenlafaxine hydrochloride dihydrate is a novel chemical entity and a potential triple monoamine reuptake inhibitor. This study characterized the in vitro triple reuptake inhibition activity, antidepressant-like activity in animals, and ...
Haibo Zhu, Wenyan Wang, Chunjie Sha, Wei Guo, Chunmei Li, Fengjuan Zhao, Hongbo Wang, Wanglin Jiang, Jingwei Tian, Jingwei Tian   +9 more
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pH-gated nanoparticles selectively regulate lysosomal function of tumour-associated macrophages for cancer immunotherapy

Nature Communications, 2023
Tumour-associated macrophages (TAMs), as one of the most abundant tumour-infiltrating immune cells, play a pivotal role in tumour antigen clearance and immune suppression.
Mingmei Tang, Binlong Chen, Heming Xia, Meijie Pan, Ruiyang Zhao, Jiayi Zhou, Qingqing Yin, Fangjie Wan, Yue Yan, Chuanxun Fu, Lijun Zhong, Qiang Zhang, Yiguang Wang   +12 more
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Novel Dual Mitochondrial and CD44 Receptor Targeting Nanoparticles for Redox Stimuli-Triggered Release

Nanoscale Research Letters, 2018
In this work, novel mitochondrial and CD44 receptor dual-targeting redox-sensitive multifunctional nanoparticles (micelles) based on oligomeric hyaluronic acid (oHA) were proposed.
Kaili Wang, Mengjiao Qi, Chunjing Guo, Yueming Yu, Bingjie Wang, Lei Fang, Mengna Liu, Zhen Wang, Xinxin Fan, Daquan Chen   +9 more
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Overcoming chemotherapy resistance via simultaneous drug-efflux circumvention and mitochondrial targeting

Acta Pharmaceutica Sinica B, 2019
Multidrug resistance (MDR) has been considered as a huge challenge to the effective chemotherapy. Therefore, it is necessary to develop new strategies to effectively overcome MDR. Here, based on the previous research of N-(2-hydroxypropyl)methacrylamide (
Minglu Zhou, Lijia Li, Lian Li, Xi Lin, Fengling Wang, Qiuyi Li, Yuan Huang   +6 more
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