Results 101 to 110 of about 2,491,987 (318)

Herbo-vitamin medicine Livogrit Vital ameliorates isoniazid induced liver injury (IILI) in human liver (HepG2) cells by decreasing isoniazid accumulation and oxidative stress driven hepatotoxicity

BMC Complementary Medicine and Therapies
Background Tuberculosis (TB) is a leading cause of infection related mortality. Isoniazid is one of the frontline drugs for anti-TB therapy. Hepatotoxicity induced by isoniazid is a major cause of drug-discontinuation which may lead to development of ...
Acharya Balkrishna, Vivek Gohel, Meenu Tomer, Rishabh Dev, Anurag Varshney   +4 more
doaj   +1 more source

Advances and Prospects for Hydrogel-Forming Microneedles in Transdermal Drug Delivery

, 2023
Transdermal drug delivery (TDD) is one of the key approaches for treating diseases, avoiding first-pass effects, reducing systemic adverse drug reactions and improving patient compliance.
Jiaqi Li, Hang Ruan, Xiaolin Hou, Meng Long, Yongyu Hong, Nianping Feng, Yongtai Zhang   +6 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Crossroad between the Heat Shock Protein and Inflammation Pathway in Acquiring Drug Resistance: A Possible Target for Future Cancer Therapeutics

, 2023
The development of multidrug resistance (MDR) against chemotherapeutic agents has become a major impediment in cancer therapy. Understanding the underlying mechanism behind MDR can guide future treatment for cancer with better therapeutic outcomes ...
Prathap Somu, Hulikunte Veeranna Jayaprakash, Nagaraj Basavegowda, Gangadahosahalli Krishnegowda Puneetha, Subhankar Paul, Kwang-Hyun Baek, Akhilesh Kumar Yadav, Levin Anbu Gomez   +7 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

TRIM37–PARP1–TET1 axis maintains stemness and prevents osteoporosis by inhibiting DNMT1 alternative splicing via 5hmC regulation

Nature Communications
The significance of DNA hydroxymethylation in replicative senescence of mesenchymal stem cells (MSCs) and aging-related osteoporosis remains unknown.
Chun-Te Ho, Ling-Hui Li, Wei-Chao Chang, Heng-Hsiung Wu, Ya-Huey Chen, Shih-Chieh Hung   +5 more
doaj   +1 more source

Agriculture, Rural Development, Food and Drug Administration, and related agencies appropriations for fiscal year 2009 : hearings before a subcommittee of the Committee on Appropriations, United States Senate, One Hundred Tenth Congress, second session on S. 3289, an act making appropriations for Agriculture, Rural Development, Food and Drug Administration, and related agencies appropriations for the fiscal year ending September 30, 2009, and for other purposes.

, 2008
Shipping list no.: 2009-0136-P."Department of Agriculture, Department of Health and Human Services: Food and Drug Administration, nondepartmental witnesses."Includes bibliographical references and indexes.Mode of access ...
United States. Congress. Senate. Committee on Appropriations. Subcommittee on Agriculture, Rural Development, Food and Drug Administration, and Related Agencies.
core  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Temporal diversity of phytochemicals in Tinospora cordifolia (Giloy), in accordance with seasonal variations: comparative analysis using UHPLC-PDA and HPTLC

BMC Plant Biology
Background Seasonal variation influences the biosynthesis and accumulation of phytochemical compounds in plants, thereby affecting the qualitative and quantitative composition of phytochemicals.
Acharya Balkrishna, Monali Joshi, Meenu Tomer, Pardeep Nain, Anurag Varshney   +4 more
doaj   +1 more source

Towards Academic Drug Development Guidelines

, 2019
This report covers academic small-molecule drug development with a view to distilling guidelines. The first section covers research productivity feeding into commercial development before reviewing the literature on statistics of academic development ...
Christopher Southan (5070713), Christopher, Southan   +1 more
core   +1 more source