Results 211 to 220 of about 2,250,283 (269)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Shifting a paradigm: highlights of model informed drug development in dosage selection and optimization for oncology products. [PDF]

Oncologist
Xiong Y, Konicki R, Zirkelbach JF, Bi Y, Okusanya O, Shord S, Rahman NA, Booth B, Li Y, Liu J, Zhu H.   +10 more
europepmc   +1 more source

Quantitative Medicine to Support Drug Development and Regulatory Decisions: A UK Regulatory Approach Informed by ICH M15. [PDF]

Clin Transl Sci
Kerwash E, Butler AS, Malamatari M, Cole S.   +3 more
europepmc   +1 more source

Small is big: growing impact of small molecule mass spectrometry in infectious disease drug development. [PDF]

mSphere
McCall L-I.
europepmc   +1 more source

Editorial: Drug development for respiratory infectious diseases and related complications in other systems. [PDF]

Front Med (Lausanne)
Yu X, Wang Y, Oliva A, Xue M.
europepmc   +1 more source

Accelerated drug development using a digital formulator and a self-driving tableting data factory. [PDF]

Nat Commun
Abbas F, Salehian M, Hou P, Moores J, Goldie J, Tsioutsios A, Tait T, Portela V, Boulay Q, Thiolliere R, Stark A, Schwartz JJ, Guerin J, Maloney AGP, Moldovan AA, Reynolds GK, Mantanus J, Clark C, Chapman P, Florence A, Markl D.   +20 more
europepmc   +1 more source

In Silico Clinical Trials in Drug Development: A Systematic Review. [PDF]

Ther Innov Regul Sci
Chen B, Schneider LC, Röver C, Comets E, Elze MC, Hooker A, IntHout J, Jannot AS, Julkowska D, Mimouni Y, Savelieva M, Stallard N, Ursino M, Vandemeulebroecke M, Weber S, Posch M, Zohar S, Friede T.   +17 more
europepmc   +1 more source

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Drug-Glycosidation and Drug Development

Mini-Reviews in Medicinal Chemistry, 2013
Ideally a drug should be administered in a form that it exerts its pharmacological action at the target site using the lowest concentration possible and without undesirable effects. Drug targeting is the approach which is followed for the purpose. Among different approaches preparation of synthetic glycosides of target drug and administering them ...
Vijay K, Kapoor, Amanpreet, Kaur
openaire   +2 more sources