Results 311 to 320 of about 4,166,507 (358)
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Drug-Glycosidation and Drug Development
Mini-Reviews in Medicinal Chemistry, 2013Ideally a drug should be administered in a form that it exerts its pharmacological action at the target site using the lowest concentration possible and without undesirable effects. Drug targeting is the approach which is followed for the purpose. Among different approaches preparation of synthetic glycosides of target drug and administering them ...
Amanpreet Kaur, Vijay Kumar Kapoor
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Antiepileptic drugs in development [PDF]
The Lancet Neurology, 2006 Despite the success of several new antiepileptic drugs, about one third of patients with epilepsy are not seizure free on medication. Improvement in this situation might lie in drugs that are currently in development.Some new antiepileptic drugs are modifications of those already available, referred to in this Rapid Review as evolutionary drugs.
John R. Pollard, Jacqueline A. French
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The Development of a Drug: A Pharmaceutical Drug Development Perspective
2020Clinical investigation of New Molecular Entities (NME) in oncology is changing. Drivers of this transformation are advances in pharmacological platforms, such as antibody technology, changes in the regulatory framework to accelerate approval of new treatments, and rapid scientific discovery.
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Drug Repurposing for Drug Development in Stroke
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2010The development of new treatments for acute stroke has been fraught with costly and spectacularly disappointing failures. Repurposing of drugs already known to be safe provides a lower risk alternative. Investigators are using drug repurposing, in which marketed drugs are exploited for their secondary activity, to pursue agents that have multiple ...
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The EORTC and drug development
European Journal of Cancer, 2002Early drug development at EORTC has always been subject to structural changes to adapt to the rapid changes that occur in oncological drug development. The expertise of early drug developers has always been cross-fertilised with disease-/tumour-oriented groups and also backwards to the laboratory research groups.
Lacombe, D. +7 more
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2008
The prevention and treatment of intracoronary thrombosis has assumed greater priority as our understanding of the pathogenesis of ischemic heart disease has increased [1,2]. The appearance of layered thrombi in healed and acute coronary plaques implies that recurrent fissuring and thrombosis lead to plaque growth and fibrosis [3, 4, 5, 6, 7].
Robert A. Harrington, Mark C. Thel
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The prevention and treatment of intracoronary thrombosis has assumed greater priority as our understanding of the pathogenesis of ischemic heart disease has increased [1,2]. The appearance of layered thrombi in healed and acute coronary plaques implies that recurrent fissuring and thrombosis lead to plaque growth and fibrosis [3, 4, 5, 6, 7].
Robert A. Harrington, Mark C. Thel
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Metabonomics and Drug Development
2015Metabolites as an end product of metabolism possess a wealth of information about altered metabolic control and homeostasis that is dependent on numerous variables including age, sex, and environment. Studying significant changes in the metabolite patterns has been recognized as a tool to understand crucial aspects in drug development like drug ...
Patrick Augustijns +3 more
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Toxicogenetics in drug development
Toxicology Letters, 2001The major progress made in the understanding of the genetic basis of inter-individual variation in drug response, alongside the rapid advances in technology, provides major new opportunities to ensure the safe introduction of a new chemical entity into clinical practice.
B. Kevin Park, Munir Pirmohamed
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2019
Allosteric regulation is a ubiquitous strategy employed in nature to control cellular processes by regulating the affinities of biomolecules. Allosteric modulators are able to tune the protein/substrate affinity in a highly predictable way, suggesting that such modulators may represent safe drugs.
Hualiang Jiang, Xi Cheng
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Allosteric regulation is a ubiquitous strategy employed in nature to control cellular processes by regulating the affinities of biomolecules. Allosteric modulators are able to tune the protein/substrate affinity in a highly predictable way, suggesting that such modulators may represent safe drugs.
Hualiang Jiang, Xi Cheng
openaire +2 more sources