Results 71 to 80 of about 2,491,987 (318)

The -Omics in drug development

, 2011
New advancement in genomics, proteomics, and metabonomics created significant excitement about the use of these relatively new technologies in drug design, discovery, development, and molecular-targeted therapeutics by identifying new drug targets and ...
Johnson, Caroline H., Robyn P. Araujo, Moridani, Majid Y., Lindon, John C., Araujo, Robyn P., Majid Y. Moridani, John C. Lindon, Caroline H. Johnson   +7 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Evidence of pseudoprogression in patients treated with PD1/PDL1 antibodies across tumor types

Cancer Medicine, 2020
Background PD(L)1 antibodies (anti‐PD(L)‐1) have been a major breakthrough in several types of cancer. Novel patterns of response and progression have been described with anti‐PD(L)‐1.
Patricia Martin‐Romano, Eduardo Castanon, Samy Ammari, Stéphane Champiat, Antoine Hollebecque, Sophie Postel‐Vinay, Capucine Baldini, Andrea Varga, Jean Marie Michot, Perrine Vuagnat, Aurélien Marabelle, Jean‐Charles Soria, Charles Ferté, Christophe Massard   +13 more
doaj   +1 more source

Mouse primary microglia respond differently to LPS and poly(I:C) in vitro

Scientific Reports, 2021
Microglia, CNS resident innate immune cells, respond strongly to activation of TLR3 and TLR4, which recognize viral dsRNA poly(I:C) and bacterial endotoxin LPS, respectively.
Yingbo He, Natalie Taylor, Xiang Yao, Anindya Bhattacharya   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Quantitative performance assessment of Ultivue multiplex panels in formalin-fixed, paraffin-embedded human and murine tumor specimens

Scientific Reports
We present a rigorous validation strategy to evaluate the performance of Ultivue multiplex immunofluorescence panels. We have quantified the accuracy and precision of four different multiplex panels (three human and one mouse) in tumor specimens with ...
Sripad Ram, Sepideh Mojtahedzadeh, Joan-Kristel Aguilar, Timothy Coskran, Eric L. Powell, Shawn P. O’Neil   +5 more
doaj   +1 more source

RNA sequencing analysis reveals quiescent microglia isolation methods from postnatal mouse brains and limitations of BV2 cells

Journal of Neuroinflammation, 2018
Background Microglia play key roles in neuron–glia interaction, neuroinflammation, neural repair, and neurotoxicity. Currently, various microglial in vitro models including primary microglia derived from distinct isolation methods and immortalized ...
Yingbo He, Xiang Yao, Natalie Taylor, Yuchen Bai, Timothy Lovenberg, Anindya Bhattacharya   +5 more
doaj   +1 more source

Biomarkers in drug development

Annals of Oncology, 2008
Due to the increasing understanding of the mechanisms relevant to the genesis of cancer, we are experiencing a transition from diseaseto target-oriented therapy. Thus the challenge of bringing new therapeutics to clinical application and registration now focuses on the molecular target expressed by the malignant cell rather than treatment of the ...
openaire   +2 more sources

Anticancer drug development /

, 2002
Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug ...
Kerr, David J., Baguley, Bruce C.
core  

DRUG DEVELOPMENT TURUNAN ASAM MEFENAMAT SEBAGAI ANALGESIK DENGAN PENDEKATAN MOLEKULER [PDF]

, 2015
Info lebih lanjut hub: Lembaga Penelitian Universitas Jember Jl. Kalimantan No.37 Telp. 0331-339385 Fax. 0331-337818 JemberPengembangan obat (Drug development) untuk mendapatkan senyawa baru yang lebih besar aktivitasnya terhadap COX untuk digunakan ...
Ayik Rosita, P
core