Results 71 to 80 of about 18,497,895 (269)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

IDB Newsletter: Vol. 8, no. 2, April 1970

, 1970
IDB Newsletter is a monthly publication of the Inter-American Development that reports on the activities of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core   +1 more source

RNA sequencing analysis reveals quiescent microglia isolation methods from postnatal mouse brains and limitations of BV2 cells

Journal of Neuroinflammation, 2018
Background Microglia play key roles in neuron–glia interaction, neuroinflammation, neural repair, and neurotoxicity. Currently, various microglial in vitro models including primary microglia derived from distinct isolation methods and immortalized ...
Yingbo He, Xiang Yao, Natalie Taylor, Yuchen Bai, Timothy Lovenberg, Anindya Bhattacharya   +5 more
doaj   +1 more source

First‐in‐Human, Healthy Volunteers Integrated Protocol of ETC‐206, an Oral Mnk 1/2 Kinase Inhibitor Oncology Drug

Clinical and Translational Science, 2020
In the last decade, drug development has tackled substantial challenges to improve efficiency and facilitate access to innovative medicines. Integrated clinical protocols and the investigation of targeted oncology drugs in healthy volunteers (HVs) have ...
Vincenzo Teneggi, Veronica Novotny‐Diermayr, Lay Hoon Lee, Maryam Yasin, Pauline Yeo, Kantharaj Ethirajulu, Sylvia Bong Hwa Gan, Stephanie E. Blanchard, Ranjani Nellore, Dhananjay N. Umrani, Roberto Gomeni, Darren Lim Wan Teck, Greg Li, Qing Shu Lu, Yang Cao, Alex Matter   +15 more
doaj   +1 more source

A novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy

mAbs, 2020
In the absence of a proven effective vaccine preventing infection by SARS-CoV-2, or a proven drug to treat COVID-19, the positive results of passive immune therapy using convalescent serum provide a strong lead.
Xiaoniu Miao, Yi Luo, Xi Huang, Suki M. Y. Lee, Zhijun Yuan, Yongzhou Tang, Liandi Chen, Chao Wang, Fan Wu, Yifeng Xu, Wenchao Jiang, Wei Gao, Xuedong Song, Yao Yan, Tuling Pang, Cheng Chen, Yuefeng Zou, Weihui Fu, Liping Wan, Javier Gilbert-Jaramillo, Michael Knight, Tiong Kit Tan, Pramila Rijal, Alain Townsend, Joanne Sun, Xiaolin Liu, William James, Andy Tsun, Yingda Xu   +28 more
doaj   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah, Martha E. Stewart, Nathan Maassel, James P. Stevens, Claudia R. Morris, Chris A. Rees   +5 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

IDB News: Vol. 2. no. 9, October 1975

, 1975
IDB News is a monthly publication of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core   +1 more source

Thyrogrit, supplemented with a sub-optimal dose of levothyroxine, restores thyroid function in rat model of propylthiouracil-induced hypothyroidism

Clinical Phytoscience
Background Hypothyroidism is a common endocrine ailment, whose current standard of care is hormonal replacement therapy with levothyroxine (LT4). There is a medical need for alternative and safer therapies as LT4 is associated with special treatment ...
Acharya Balkrishna, Ritu Paliwal, Madhulina Maity, Yash Varshney, Sandeep Sinha, Anurag Varshney   +5 more
doaj   +1 more source

Development of a modified lymphocyte transformation test for diagnosing drug-induced liver injury associated with an adaptive immune response

Journal of Immunotoxicology, 2017
Drug-induced liver injury (DILI) is a growing problem. Diagnostic methods to differentiate DILI caused by an adaptive immune response from liver injury of other causes or to identify the responsible drug in patients receiving multiple drugs, herbals and ...
Jessica Whritenour, Mira Ko, Qing Zong, Jianying Wang, Karrie Tartaro, Patricia Schneider, Ellen Olson, Maria Van Volkenburg, Jose Serrano, Paul Hayashi, Robert Fontana, Naga Chalasani, Herbert L. Bonkovsky   +12 more
doaj   +1 more source