Results 291 to 300 of about 5,239,733 (368)

The MMP‐9/TIMP‐1 Ratio and Concentrations of Osteopontin Are Elevated in Cerebrospinal Fluid of People With Multiple Sclerosis and Decrease After Autologous Hematopoietic Stem Cell Transplantation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic, Ida Erngren, Kim Kultima, Anders Larsson, Malin Müller, Anna Wiberg, Joachim Burman   +6 more
wiley   +1 more source

Addressing infectious diseases in Africa by accelerating drug discovery through data science. [PDF]

Commun Med (Lond)
Turon G, Hlozek J, Duran-Frigola M, Chibale K, Woodland JG.   +4 more
europepmc   +1 more source

Exploring Advanced Methodologies for NS5 Methyltransferase Targeted Drug Discovery

Tomáš Otava, Matúš Drexler, Petra Krafcikova, Dominika Chalupska, Karel Chalupský, Vaclav Veverka, Evzen Boura, Radim Nencka   +7 more
openalex   +1 more source

Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou, Carl D. Langefeld, Padmini Sekar, Mary Comeau, Timothy Howard, Tamara N. Kimball, Chen Bowang, Hyacinth I. Hyacinth, Jonathan Rosand, Christopher D. Anderson, Caspar Grond‐Ginsbach, Daniel Woo, Stacie L. Demel   +12 more
wiley   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives. [PDF]

Chempluschem
Roscales S, Csáky AG.
europepmc   +1 more source

Radioprotection redefined: drug discovery at the intersection of tardigrade biology and translational pharmacology. [PDF]

Front Pharmacol
Cui Z, Lin C, Zhao H, Wang X.
europepmc   +1 more source

The Role of Nucleotide Sequencing in Natural Product Drug Discovery. [PDF]

J Nat Prod
Waterworth SC.
europepmc   +1 more source

Computational Landscape in Drug Discovery: From AI/ML Models to Translational Application. [PDF]

Scientifica (Cairo)
Sharma D, Anabala M, Jain VV, Shyam M, Prince SE, Muniyan R.   +5 more
europepmc   +1 more source

Use of a cytochrome P450 humanised mouse model to refine schistosomiasis drug discovery

Davey SD, Forde-Thomas JE, Hulme BJ, Lees K, Costain AH, Evans M, Rinaldi G, Frame L, Stojanovski L, Simeons FRC, Tavendale A, Kenneth MacLeod A, Pichon R, Lee Y, Polak O, Chalmers IW, Dankwa B, Odhiambo BK, Guimaraes VH, Hegarty M, Swain MT, Aubrey W, Caldwell N, MacDonald AS, Gilbert IH, Baragaña B, Read KD, Hoffmann KF.   +27 more
europepmc   +1 more source