Results 291 to 300 of about 1,411,950 (341)
Use of a cytochrome P450 humanised mouse model to refine schistosomiasis drug discovery
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Current Topics in Medicinal Chemistry, 2003
In recent years, tools for the development of new drugs have been dramatically improved. These include genomic and proteomic research, numerous biophysical methods, combinatorial chemistry and screening technologies. In addition, early ADMET studies are employed in order to significantly reduce the failure rate in the development of drug candidates. As
Oliver, Schwardt +2 more
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In recent years, tools for the development of new drugs have been dramatically improved. These include genomic and proteomic research, numerous biophysical methods, combinatorial chemistry and screening technologies. In addition, early ADMET studies are employed in order to significantly reduce the failure rate in the development of drug candidates. As
Oliver, Schwardt +2 more
openaire +2 more sources
Expert Opinion on Drug Discovery, 2007
Ayurveda is a major traditional system of Indian medicine that is still being successfully used in many countries. Recapitulation and adaptation of the older science to modern drug discovery processes can bring renewed interest to the pharmaceutical world and offer unique therapeutic solutions for a wide range of human disorders. Eventhough time-tested
Premalatha, Balachandran +1 more
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Ayurveda is a major traditional system of Indian medicine that is still being successfully used in many countries. Recapitulation and adaptation of the older science to modern drug discovery processes can bring renewed interest to the pharmaceutical world and offer unique therapeutic solutions for a wide range of human disorders. Eventhough time-tested
Premalatha, Balachandran +1 more
openaire +2 more sources
Drug Discovery Paradigms: Phenotypic-Based Drug Discovery
2022A drug discovery and development project typically starts with the identifcation of novel active scaffolds, i.e., core chemical structures with a desired biological effect. Beyond serendipitous discoveries and fndings based on ethnopharmacology/traditional medicine, drug discovery in the modern age has been guided by two fundamental screening ...
Talevi, Alan, Bellera, Carolina Leticia
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Nature Reviews Drug Discovery, 2003
Millions of people suffer from a wide variety of ocular diseases, many of which lead to irreversible blindness. The leading causes of irreversible blindness in the elderly--age-related macular degeneration and glaucoma--will continue to effect more individuals as the worldwide population continues to age.
Abbot F, Clark, Thomas, Yorio
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Millions of people suffer from a wide variety of ocular diseases, many of which lead to irreversible blindness. The leading causes of irreversible blindness in the elderly--age-related macular degeneration and glaucoma--will continue to effect more individuals as the worldwide population continues to age.
Abbot F, Clark, Thomas, Yorio
openaire +2 more sources