Results 291 to 300 of about 5,785,146 (400)

Large Language Models and Their Applications in Drug Discovery and Development: A Primer. [PDF]

Clin Transl Sci
Lu J, Choi K, Eremeev M, Gobburu J, Goswami S, Liu Q, Mo G, Musante CJ, Shahin MH.   +8 more
europepmc   +1 more source

Glycosylation Gene Signatures as Prognostic Biomarkers in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioblastoma (GBM) is an aggressive brain tumor characterized by significant heterogeneity. This study investigates the role of glycosylation‐related genes in GBM subtyping, prognosis, and response to therapy. Methods We analyzed mRNA expression data and clinical information from The Cancer Genome Atlas (TCGA) and Gene Expression ...
Tong Zhao, Hongliang Ge, Chenchao Lin, Xiyue Wu, Jianwu Chen   +4 more
wiley   +1 more source

Unveiling Dynamic Hotspots in Protein-Ligand Binding: Accelerating Target and Drug Discovery Approaches. [PDF]

Int J Mol Sci
Trezza A, Visibelli A, Roncaglia B, Barletta R, Iannielli S, Mahboob L, Spiga O, Santucci A.   +7 more
europepmc   +1 more source

Erratum: Genomics and proteomics: The new millenium of drug discovery and development

, 2001
Mary Jane Cunningham
openalex   +1 more source

Nuclei‐Specific Amygdala Enlargement Is Linked to Psychiatric Comorbidities in Drug‐Resistant Focal Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amygdala enlargement has been the subject of controversial studies regarding its significance in terms of pathogenicity both in epilepsy and in psychiatric comorbidities such as anxiety, depression, and post‐traumatic stress disorder.
Hélène Mourre, Julia Makhalova, Lisa Soncin, Elodie Garnier, Hugo Dary, Arnaud Le Troter, Roy A. M. Haast, Benoit Testud, Marie Arthuis, Samuel Medina Villalon, Stanislas Lagarde, Francesca Pizzo, Christian Bénar, Jean‐Philippe Ranjeva, Maxime Guye, Fabrice Bartolomei   +15 more
wiley   +1 more source

A guide for active learning in synergistic drug discovery. [PDF]

Sci Rep
Wang S, Allauzen A, Nghe P, Opuu V.
europepmc   +1 more source

The Impact of Diabetes and Metabolic Syndrome Burden on Pain, Neuropathy Severity and Fiber Type

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Determine the association between diabetes and metabolic syndrome (MetS) burden (number of MetS criteria fulfilled) and pain, neuropathy severity, and fiber type involvement in individuals with established polyneuropathy. Methods The Peripheral Neuropathy Research Registry was queried for individuals with type 1 and type 2 diabetes ...
Long Davalos, Brian C. Callaghan, Lavanya Muthukumar, Simone Thomas, Evan L. Reynolds, A. Gordon Smith, J. Robinson Singleton, Ahmet Höke, Senda Ajroud‐Driss, Mazen M. Dimachkie, Stefanie Geisler, David M. Simpson, PNRR Study Group, Amro M. Stino   +13 more
wiley   +1 more source

Transforming Drug Discovery with Miniaturized Predictive Tissue Models. [PDF]

Micromachines (Basel)
Akbari M.
europepmc   +1 more source

Potential molecular targets for anti-obesity drugs. After the discovery of leptin.

, 2001
Shuji Hidaka, Yoshihiro Ogawa, Kazuwa Nakao   +2 more
openalex   +2 more sources

Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 PD patients undergoing levodopa challenges with and without prior transcranial direct current stimulation targeting a defined PD response network ...
Lukas L. Goede, Patricia Zvarova, Bahne H. Bahners, Andreas Horn   +3 more
wiley   +1 more source