Results 61 to 70 of about 889,481 (299)

Viral population estimation using pyrosequencing [PDF]

, 2008
The diversity of virus populations within single infected hosts presents a major difficulty for the natural immune response as well as for vaccine design and antiviral drug therapy.
A Dempster, A Rambaut, AMN Tsibris, B Gaschen, Baback Gharizadeh, C Wang, Chunlin Wang, D O'Meara, DC Douek, E Domingo, E Halperin, EH Simpson, ES Lander, Glenn Tesler, GS Gottlieb, GW Tyson, H Fakhrai-Rad, I Malet, IM Rouzine, J Kececioglu, JE Hopcroft, JF Simons, K Chen, KJ Metzner, L Bacheler, L Doukhan, L Excoffier, Lior Pachter, LR Ford, M Breitbart, M Eigen, M Margulies, M Stephens, MA Nowak, MJ Gonzales, ML Collins, ML Sogin, Mostafa Ronaghi, MT Tammi, N Beerenwinkel, Nicholas Eriksson, Niko Beerenwinkel, P Jenkins, PA Pevzner, R Schmid, R Shankarappa, Robert W. Shafer, RP Dilworth, S Huse, S-Y Rhee, S-Y Rhee, Soo-Yon Rhee, VA Johnson, Yumi Mitsuya   +53 more
core   +7 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Medication errors in hematology-oncology ward by consultation : the role of the clinical pharmacologist

Caspian Journal of Internal Medicine, 2021
Background: The aim was to describe, evaluate and document the prevention of medication errors by clinical pharmacologist consultations in patients with cancer.
Ali Eishy Oskoyi, Hamdollah Sharifi, Rahim Asghari   +2 more
doaj  

MEDICATION ERRORS IN OUTPATIENTS OF A GOVERNMENT HOSPITAL IN YOGYAKARTA INDONESIA [PDF]

, 2010
Background. Medication errors are important problems in hospitalized patients. Medication errors are inevitable and are affected by human factors. Nevertheless, the epidemiological data about medication errors in outpatients in Indonesia is still limited.
Abror, Jamiul, Perwitasari, Dyah Aryani, Wahyuningsih, Iis   +2 more
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Improvements on the Inhaler [PDF]

, 2020
Background: Inhalers are a commonplace in American health care and deliver crucial drugs to patients with COPD and asthma. Inhaler use has been shown to be unsatisfactory among patients resulting in ineffective medication delivery.
Evensky, Jesse, Freid, Bradley, Kane, MD, Gregory C., Malkani, Kabir, Reibstein, Alex   +4 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Analysis of Compounded Pharmaceutical Products to Teach the Importance of Quality in an Applied Pharmaceutics Laboratory Course [PDF]

, 2014
Objective. To assess the effectiveness of a product-analysis laboratory exercise in teaching students the importance of quality in pharmaceutical compounding. Design.
Almoazen, Birnie, Eley, Hinkle, Kadi, McGill, Newton, Pignato, Shrewsbury, Shrewsbury   +9 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Medication errors in anesthesia: unacceptable or unavoidable?

Revista Brasileira de Anestesiologia
Medication errors are the common causes of patient morbidity and mortality. It adds financial burden to the institution as well. Though the impact varies from no harm to serious adverse effects including death, it needs attention on priority basis since ...
Ira Dhawan, Anurag Tewari, Sankalp Sehgal, Ashish Chandra Sinha   +3 more
doaj   +1 more source