Results 121 to 130 of about 30,389 (194)
Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis)
Abstract Background The cynomolgus macaque has become the most used non‐human primate species in nonclinical safety assessment during the past decades. Methods This review summarizes the biological data and organ system development milestones of the cynomolgus macaque available in the literature.
Xiantang Li+5 more
wiley +1 more source
Disease features, treatments, and burden of palmoplantar pustulosis in Korea: The EPPPIK study
Abstract Palmoplantar pustulosis (PPP) is a chronic skin disease characterized by erythema, pustules, and desquamation of the palms and soles. PPP epidemiological data are scarce. Understanding disease characteristic is essential for effective management and to reduce burden.
Seong Jin Jo+12 more
wiley +1 more source
We, campesinos: The potentials and pitfalls of agrarian populism in Colombia's agrarian strike
Abstract This contribution aims to explore the potentials and pitfalls for the emergence of a popular agrarian movement capable of offering a progressive alternative to the far‐right. Taking the case of Colombia's national agrarian strike, the paper argues that food sovereignty can offer a mobilizing framework for a multiclass, antineoliberal agrarian ...
Kyla Sankey
wiley +1 more source
This article explores temporal and ethical presents in a dementia ward in Denmark. Dementia wards are often portrayed and experienced as uncanny places where time stands still or becomes radically distorted. I approach the ward, however, as an encounter or access into experiences of time that are hidden from view in the outside world where common‐sense
Lone Grøn
wiley +1 more source
ABSTRACT Acne vulgaris is a common inflammatory condition that is often treated by dermatologists with isotretinoin. Isotretinoin has a number of effects on inflammatory pathways, with clear efficacy in managing acne vulgaris. There are also well‐documented side effects of isotretinoin, including hyperlipidemia; however, the overall cardiovascular risk
Timothy L. Cowan+3 more
wiley +1 more source
Targeted Therapies for Slow‐Flow Vascular Malformations
ABSTRACT Advances in genetic sequencing technologies have enabled the identification of key activating somatic variants in cellular signalling pathways involved in the pathogenesis of vascular malformations. Given that these genetic variants are also implicated in the pathogenesis of several cancers, the repurposing of targeted therapies developed in ...
Grace X. Li+2 more
wiley +1 more source
Feedback regulation of VISTA and Treg by TNF‐α controls T cell responses in drug allergy
TNF‐α breaks immune tolerance by regulating the VISTA at early stage of the drug‐specific T‐cell response. The response of drug‐responsive effector T cells was negative feedback regulated by increasing Treg cells. This indicates that Treg agonists, rather than TNF‐α antagonists, could be used to treat patients with progressive SCARs.
Lele Sun+14 more
wiley +1 more source
This study investigates the role of mitochondrial fission in keratinocyte apoptosis in blister fluid‐derived exosomes from patients with SJS/TEN, erythema multiforme, and in healthy individuals. Galectin‐7 is upregulated in exosomes of patients with SJS/TEN and shows a correlation with disease severity.
Chen Zhang+16 more
wiley +1 more source
S-Carboxymethyl-L-cysteine-induced Fixed Drug Eruption
Hidetsugu Fukuda, Misaki Takahashi
doaj +1 more source