Results 141 to 150 of about 30,389 (194)

Treatment options for immune‐related adverse events associated with immune checkpoint inhibitors

British Journal of Pharmacology, EarlyView.
Abstract The immunotherapy revolution with the use of immune checkpoint inhibitors (ICIs) started with the clinical use of the first ICI, ipilimumab, in 2011. Since then, the field of ICI therapy has rapidly expanded — with the FDA approval of 10 different ICI drugs so far and their incorporation into the therapeutic regimens of a range of malignancies.
Yu Hua Chen, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

A Multicenter Phase II Trial of Nimustine Hydrochloride Administered via Convection‐Enhanced Delivery in Children With DIPG

Cancer Science, EarlyView.
The efficacy of the CED of nimustine hydrochloride in pediatric DIPG was evaluated. One‐year survival rate from the start of radiotherapy was 60%. The treatment strategy demonstrated potential efficacy. ABSTRACT Diffuse intrinsic pontine glioma (DIPG) is a very challenging‐to‐treat pediatric malignant tumor, with a median survival time of < 12 months ...
Ryuta Saito, Masayuki Kanamori, Yoshiki Arakawa, Yohei Mineharu, Yasuo Aihara, Kentaro Chiba, Toshihiro Kumabe, Ichiyo Shibahara, Yukihiko Sonoda, Kenichiro Matsuda, Manabu Kinoshita, Aya Sato, Fumiaki Takahashi, Teiji Tominaga   +13 more
wiley   +1 more source

Classification of direct threats to the conservation of ecosystems and species 4.0

Conservation Biology, EarlyView.
Abstract Identifying and assessing the magnitude of direct threats to ecosystems and species are critical steps to prioritizing, planning, implementing, and assessing conservation actions. Just as medical clinicians and researchers need a standard way to talk about human diseases, conservation practitioners and scientists need a common and ...
Nick Salafsky, Claire Relton, Bruce E. Young, Philippe Lamarre, Monika Böhm, Maxime Chénier, Erica Cochrane, Mark Dionne, Kevin K. He, Craig Hilton‐Taylor, Charles Latrémouille, John Morrison, Calla V. Raymond, Mary Seddon, Varsha Suresh   +14 more
wiley   +1 more source

The room where it happened: How evangelical leaders used a Closed‐Door meeting to change sentiment for Donald J. Trump

The Australian Journal of Anthropology, Volume 33, Issue 3, Page 349-359, December 2022., 2022
The embrace of Donald J. Trump as a presidential candidate in 2016 was not a given for evangelical voters. The thrice married, one‐time advocate for abortion, who prided himself on his ability to attract beautiful women did not seem like someone for whom evangelicals would enthusiastically show up to vote.
J. Derrick Lemons
wiley   +1 more source

Clinical characteristics and treatment outcomes of linear IgA bullous dermatosis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Linear immunoglobulin A (IgA) bullous dermatosis (LABD), also referred to as chronic bullous disease of childhood (CBDC), is characterized by the linear deposition of IgA antibodies within the dermal‐epidermal junction. While dapsone is typically recommended, alternative modalities may be considered based on accessibility, severity, and prior ...
Kristie Mar, Fiona Landells, Bushra Khalid, Aswen Sriranganathan, Ou Jia Wang, Samantha Y. Starkey, Ivan V. Litvinov, Ilya Mukovozov   +7 more
wiley   +1 more source

Cefotaxime induced generalized bullous fixed drug eruption - A case report

Toxicology Reports, 2018
Fixed drug eruption (FDE) is the most common cutaneous adverse drug reaction. Cefotaxime, a broad-spectrum third-generation cephalosporin, appeared to be a safe and effective therapy in greater than 90% of infections including cellulitis, abscesses and ...
R. Manikandan, A. Porselvi, G.C. Keerthana, K. Vaishnavi, S. Girija, Murali Narasimhan, TM. Vijayakumar   +6 more
doaj  

Preventing financial ruin: How the West India trade fostered creativity in crisis lending by the Bank of England

The Economic History Review, EarlyView.
Abstract This paper contributes to the understanding of the complex relationship between British economic performance during the Napoleonic wars and the ‘West Indies’, as the Caribbean slave colonies were called. Not only did profits from slave‐based commerce provide financing for the growth of the financial sector, as has been claimed, but the risk of
Carolyn Sissoko, Mina Ishizu
wiley   +1 more source

The Individuality of Meaning in Life

European Journal of Philosophy, EarlyView.
Abstract In contemporary philosophical discourse, there is a widespread assumption that meaning in life is individual: that it is a value inherent in individual human lives, that the content of this meaning varies from individual to individual, and that it differs in degree based on the individual. Despite these claims, however, objectivist theories of
Roland Kipke
wiley   +1 more source

Estradiol Valerate Tablets Caused Rare Severe Drug Eruption: The First Reported Case

Clinical, Cosmetic and Investigational Dermatology
Fang Yang, Yuedan Xu, Xiangyu Li Department of Pharmacy, Shaoxing Keqiao Women & Children΄s Hospital, Shaoxing, Zhejiang, People’s Republic of ChinaCorrespondence: Xiangyu Li, Department of Pharmacy, Shaoxing Keqiao Women & Children΄s Hospital, Shaoxing,
Yang F, Xu Y, Li X
doaj  

Comparative risk of major health events among individuals prescribed different antiseizure medications following ischemic stroke

Epilepsia, EarlyView.
Abstract Objective The aim of this study was to compare the risk of seizure, recurrent stroke, fall or fracture, and mortality in individuals prescribed different antiseizure medications (ASMs) following an ischemic stroke. Methods We identified all patients admitted to a Victorian public or private hospital with a principal diagnosis of an incident ...
Stella Jung‐Hyun Kim, Clara Marquina, Emma Foster, J. Simon Bell, Jenni Ilomäki   +4 more
wiley   +1 more source