Results 271 to 280 of about 265,822 (283)
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Preclinical Models for Evaluating Topoisomerase I-Targeted Drugs

2005
Type I and II DNA topoisomerases are the targets for numerous clinically efficacious antitumor agents. Over the last decade, considerable effort has been expended in developing camptothecin (CPT) derivatives that selectively target DNA topoisomerase I (TOP-I) (1).
Clinton F. Stewart   +4 more
openaire   +2 more sources

Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and Safety

2015
The drug discovery process is a series of interrelated, bidirectional steps culminating in the declaration of an investigational new drug. Upon selection of a disease target and initiation of drug screening and chemistry efforts, secondary and tertiary assays to assess the efficacy and safety of potential lead candidates or develop biomarkers to ...
Lauren Keith   +2 more
openaire   +2 more sources

Significance of neurochemical parameters in the preclinical evaluation of neuroleptic drugs

Pharmacology & Therapeutics, 1979
Antonio Groppetti   +3 more
openaire   +3 more sources

Preclinical evaluation of flesinoxan as a potential anxiolytic and antidepressant drug

European Journal of Pharmacology, 1990
Schipper Jacques   +6 more
openaire   +2 more sources

Preclinical evaluation of anti-CD269 antibody–drug conjugates

European Journal of Cancer, 2016
C. Lutz   +5 more
openaire   +2 more sources

[Preclinical/toxicologic evaluation of drugs].

Ugeskrift for laeger, 1999
Knudsen, Lisbeth E.   +2 more
openaire   +1 more source

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