Results 341 to 350 of about 18,950,887 (401)
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The Epidemiological Evaluation of Drugs
Acta Medica Scandinavica, 1984ABSTRACT. Depending on the research problem, the epidemiological evaluation of drugs must be based on a combination of research strategies that include experimental methods (controlled trials), and non‐experimental methods. Among the latter are correlational studies; spontaneous reporting systems and published case reports; cohort studies; and case ...
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Evaluation of drug–drug interactions with fesoterodine
European Journal of Clinical Pharmacology, 2009To assess drug-drug interactions of fesoterodine with cytochrome P450 (CYP) 3A4 inhibitor (ketoconazole), inducer (rifampicin), and substrates (ethinylestradiol and levonorgestrel).Effects of ketoconazole 200 mg twice daily and rifampicin 600 mg twice daily on fesoterodine 8 mg once daily were investigated in CYP2D6 extensive metabolizers (EMs) and ...
Bimal Malhotra +2 more
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Biomimetic microfluidic device for in vitro antihypertensive drug evaluation.
Molecular Pharmaceutics, 2014Microfluidic devices have emerged as revolutionary, novel platforms for in vitro drug evaluation. In this work, we developed a facile method for evaluating antihypertensive drugs using a microfluidic chip.
Lei Li +5 more
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An Overview of Machine Learning and Big Data for Drug Toxicity Evaluation.
Chemical Research in Toxicology, 2020Drug toxicity evaluation is an essential process of drug development as it is reportedly responsible for the attrition of approximately 30% of drug candidates.
Andy H. Vo +4 more
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Evaluation of the teratogenicity of drugs
Clinical Pharmacology & Therapeutics, 1964The detection of the teratogenic effect of drugs remains a challenge. The sudden appearance of the problem has baffled pharmacologists. The testing of the teratogenic action of a new drttg requires a systematic and complete investigation, without bias, based on the chemical s1rttctttre or pharmacologic action.
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Miniaturized three-dimensional cancer model for drug evaluation.
Assay and drug development technologies, 2013A more relevant in vitro cell culture model that closely mimics tumor biology and provides better predictive information on anticancer therapies has been the focus of much attention in recent years.
C. Lovitt, T. Shelper, V. Avery
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Drug safety evaluation of desogestrel
Expert Opinion on Drug Safety, 2013Desogestrel (DSG) is a third-generation progestin. It is commonly used in various formulations for hormonal contraception including combinations with ethinyl estradiol (EE), progestin-only pill and subdermal implants. DSG is also used in menopausal patients for hormone replacement therapy (HRT).The current manuscript aims to review the available data ...
SCALA, CAROLINA +4 more
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Journal of the American Medical Association (JAMA), 2000
The effects of drug dependence on social systems has helped shape the generally held view that drug dependence is primarily a social problem, not a health problem. In turn, medical approaches to prevention and treatment are lacking.
T. McLellan +3 more
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The effects of drug dependence on social systems has helped shape the generally held view that drug dependence is primarily a social problem, not a health problem. In turn, medical approaches to prevention and treatment are lacking.
T. McLellan +3 more
semanticscholar +1 more source
DataWarrior: an evaluation of the open-source drug discovery tool
Expert Opinion on Drug Discovery, 2019Introduction: DataWarrior is open and interactive software for data analysis and visualization that integrates well-established and novel chemoinformatics algorithms in a single environment.
Edgar López-López +2 more
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Drug Evaluation by Council on Drugs
JAMA: The Journal of the American Medical Association, 1963WHEN A PHYSICIAN writes a prescription for a completely new drug, it is a moment of great decision. He has had to assess a welter of claims before deciding to use a new drug in preference to one of the older drugs that he knows well. Many hopes rest on that moment.
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