Results 201 to 210 of about 1,960,750 (298)

The Successful Management of Severe Leptospirosis by Using Meropenem and Corticosteroids in the Setting of Multi-Drug Hypersensitivity: A Case Report. [PDF]

Cureus
Deans N, Merybal M, Ashwin J, Ajoy Kadavan R.   +3 more
europepmc   +1 more source

Epilepsy‐associated SCN2A‐L1342P mutation drives network hyperexcitability and widespread transcriptomic changes in human cortical organoids

Epilepsia, EarlyView.
Abstract Objective SCN2A pathogenic mutations, such as the recurrent heterozygous Nav1.2‐L1342P, are monogenic causes of epilepsy. In this human‐induced pluripotent stem cell–derived model system, we aim to investigate the molecular and cellular mechanisms underlying SCN2A‐L1342P‐associated pathology. Methods Using a human male induced pluripotent stem
Maria I. Olivero‐Acosta, Morgan Robinson, Zhefu Que, Zaiyang Zhang, Karen V. Salazar‐Salazar, Hope Elizabeth Harlow, Vinayak Shankar, Seoyeon Hong, Muhan Wang, Conrad M. Otterbacher, Hina Kadono, Manasi Halurkar, Harish Kothandaraman, Nadia Atallah Lanman, Trang Nguyen, Kyle Wettschurack, Benjamin Zirkle, Layan Yunis, Ningren Cui, Xiaoling Chen, Jingliang Zhang, Jiaxiang Wu, William C. Skarnes, Chongli Yuan, Feng Guo, Megan Abbott, Yang Yang   +26 more
wiley   +1 more source

Blended reactions and angioedema are common in patients with cross-reactive nonsteroidal anti-inflammatory drug hypersensitivity. [PDF]

Asia Pac Allergy
Pham DL, Le HD, Nguyen DK, Nguyen VH, Man Ly N, Le HTB, Nguyen SXH, Nguyen LD, Mai TTN, Nguyen KA, Luu QQ, Trinh HKT.   +11 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Prevalence and management of immediate drug hypersensitivity observed during antineoplastic drug therapy. [PDF]

Acta Oncol
Rasmussen TH, Mortz CG, Pfeiffer P, Andersen N, Bindslev-Jensen C.   +4 more
europepmc   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

Editorial: Biomarkers in Drug Hypersensitivity

Frontiers in Pharmacology, 2017
José A. G. Agúndez, Silvia Selinski, Emanuela Corsini, Klaus Golka, Elena García-Martín   +4 more
doaj   +1 more source

The impact of repeated drug desensitisation on quality of life in drug hypersensitivity. [PDF]

Clin Transl Allergy
Gorgulu Akin B, Kepil Ozdemir S, Doganay Erdogan B, Gelincik A, Goksel O, Dursun AB, Isık SR, Demir S, Akten HS, Bavbek S.   +9 more
europepmc   +1 more source

Composition of allogeneic equine orthobiologics and their repeated intra‐articular administrations

Equine Veterinary Journal, EarlyView.
Abstract Background Orthobiologics such as platelet‐rich plasma (PRP) and alpha‐2‐macroglobulin (A2MG) are increasingly used for equine musculoskeletal injuries. However, their composition and safety with repeated allogeneic intra‐articular administration remain poorly investigated.
Yanne Van Reusel, Sarah Y. Broeckx, Anna Carolo, Marco Patruno, Jonas Steenbrugge, Jimmy Saunders, Enrico Gugliandolo, Jan H. Spaas   +7 more
wiley   +1 more source

Immediate Hypersensitivity Reaction to Pheniramine in a Case of Multiple Drug Hypersensitivity Syndrome. [PDF]

Cureus
Dik S, Özden G, Cevirme L, Erkoc M, Basir H.   +4 more
europepmc   +1 more source