Results 321 to 330 of about 3,996,783 (390)

A case of antiepileptic drug hypersensitivity syndrome by lamotrigine mimicking infectious mononucleosis and atypical Kawasaki disease

, 2009
Su Jung Yoo, Ihl Sung Park, Eun Sook Suh
openalex   +1 more source

Mechanism‐Based Modeling Approaches to Quantify the Effect of Immunogenicity on the Pharmacokinetics of Therapeutic Proteins in Drug Development

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Therapeutic protein administration in both preclinical and clinical studies can result in the formation of anti‐drug antibodies against the therapeutic protein. Anti‐drug antibody formation may alter the pharmacokinetics of the therapeutic protein, reduce its plasma concentrations, increase exposure variability, and may lead to a loss of ...
Paridhi Gupta, Josiah T. Ryman, Vibha Jawa, Bernd Meibohm   +3 more
wiley   +1 more source

Diclofenac Hypersensitivity: Antibody Responses to the Parent Drug and Relevant Metabolites

, 2010
Andrea Harrer, Roland Lang, Robert Grims, Michaela Braitsch, Thomas Hawranek, Werner Aberer, Lothar Vogel, Walther Schmid, Fátima Ferreira, Martin Himly   +9 more
openalex   +2 more sources

Microneedle delivery systems for vaccines and immunotherapy

Smart Molecules, EarlyView.
This paper reviews the preparation methods and materials of microneedles for drug delivery, summarizes the structures and types of microneedle systems, analyzes the influence of antigens and adjuvants on the efficacy of microneedle vaccines, and reviews the current application status of microneedles in the fields of vaccines and immunotherapy by ...
Haiyao Jia, Jinyuan Liu, Mengqian Shi, Manzar Abbas, Ruirui Xing, Xuehai Yan   +5 more
wiley   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B‐Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations

Small Methods, EarlyView.
This work presents an integrated set of methods to evaluate the efficacy of asparaginase formulations against B‐cell Acute Lymphoblastic Leukemia (ALL) in mice, including the establishment of an ALL murine model, an amino acid depletion study using high‐performance liquid chromatography (HPLC), and comprehensive assessment of antibody production ...
Julien Santelli, Annie Y. Heble, Connor Endsley, Adam Woodward, Nazia Hafeez, Naomi Winick, Jacques Lux   +6 more
wiley   +1 more source

Dissecting Microscopic Colitis Immunopathophysiology: Insights From Basic Research

United European Gastroenterology Journal, EarlyView.
ABSTRACT Microscopic colitis is an inflammatory bowel disease (IBD) comprising two clinically undiscernible entities: collagenous colitis and lymphocytic colitis. Collagenous colitis associates with HLA genes and displays a Th1/Tc1–Th17/Tc17 profile with pericryptal myofibroblast activity, water malabsorption and secondary fluid loss due to altered ...
Andreas Münch, Celia Escudero‐Hernández   +1 more
wiley   +1 more source

Deciphering the panvascular immune landscape of atherosclerosis

VIEW, EarlyView.
Atherosclerosis (AS) involves inflammation in major arteries and can cause severe cardiovascular events like heart attacks and strokes, yet disease patterns vary significantly between arteries, complicating diagnosis and treatment. In this study, we integrated transcriptomic and single‐cell RNA sequencing data from AS plaques across five key arterial ...
Yiming Zhong, Yifan Chen, Yuehong Wang, Wenhai Pan, Honghao Huang, Lin Lin Cao, Yili Wang, Jiawen Zhang, Yunyi Liang, Xiangyue Qian, Chenxi Shi, Xiyuan Lu, Jun Pu   +12 more
wiley   +1 more source

How pandemics reshape our brain: Common links and targets between long‐haul COVID‐19, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), oxidative stress, and neurodegeneration

Neuroprotection, EarlyView.
Mary E. Herman
wiley   +1 more source

Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Chronic rhinosinusitis (CRS), a complex inflammatory disease with heterogeneous pathogenesis, demands evolving evidence‐based strategies. Since the 2018 Chinese guidelines and EPOS2020, international advances in CRS immunopathology and biologics have revolutionized therapeutic approaches, particularly through phenotype–endotype classification ...
Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association   +4 more
wiley   +1 more source