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Drug Hypersensitivity Syndrome
Dermatology, 1993Some types of hypersensitivity to drugs are defined either by the generic name of the drug or descriptive terms. They are sometimes assimilated to pseudolymphoma because the causative drugs are often the same, although the eruption lacks clinical and histopathological criteria of pseudolymphoma.
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Murine models of drug hypersensitivity
Current Opinion in Allergy & Clinical Immunology, 2005Drug hypersensitivity reactions are relatively rare but may result in severe morbidity and fatalities. Due to the idiosyncratic nature and multifactorial etiology of these reactions, development of a single animal model to study the immunosensitizing mechanisms of all drugs is impossible. This hampers the development of predictive screening models that
Nierkens, S., Pieters, R.
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Medical Journal of Australia, 2006
Most drug reactions are pharmacological reactions rather than hypersensitivity reactions. In assessing drug reactions, a detailed clinical history and careful documentation of reactions are most important. Elucidating the nature and time course (first versus subsequent exposure, immediate versus non-immediate) of a reaction can help to distinguish ...
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Most drug reactions are pharmacological reactions rather than hypersensitivity reactions. In assessing drug reactions, a detailed clinical history and careful documentation of reactions are most important. Elucidating the nature and time course (first versus subsequent exposure, immediate versus non-immediate) of a reaction can help to distinguish ...
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Danger Signs in Drug Hypersensitivity
Medical Clinics of North America, 2010ADRs are frequently considered iatrogenic complications and, therefore, pose a specific challenge for the physician-patient relationship. Early recognition of a potential ADR is possible, especially on the skin, in addition to characteristic clinical danger signs. Cutaneous manifestations are variable, depending on the causative pathomechanism.
Scherer, Kathrin, Bircher, Andreas J.
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Drug metabolism and hypersensitivity reactions to drugs
Current Opinion in Allergy & Clinical Immunology, 2015The aim of the present review was to discuss recent advances supporting a role of drug metabolism, and particularly of the generation of reactive metabolites, in hypersensitivity reactions to drugs.The development of novel mass-spectrometry procedures has allowed the identification of reactive metabolites from drugs known to be involved in ...
José A. G. Agúndez +2 more
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HLA and Pharmacogenetics of Drug Hypersensitivity
Pharmacogenomics, 2012Immunologically mediated drug reactions have been traditionally classified as unpredictable based on the fact that they cannot be predicted strictly on the pharmacological action of the drug. Such adverse drug reactions are associated with considerable morbidity and include severe cutaneous adverse reactions such as Stevens-Johnson syndrome/toxic ...
Rebecca Pavlos +3 more
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Epidemiology of hypersensitivity drug reactions
Current Opinion in Allergy & Clinical Immunology, 2005Hypersensitivity drug reactions are but one of the many different types of adverse drug reactions. They may be potentially life-threatening, prolong hospitalization, affect drug prescribing patterns of physicians and result in socioeconomic costs. This review summarizes current knowledge on the incidence, prevalence, mortality and risk factors for ...
Pascal Demoly, Eva Rebelo Gomes
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Hypersensitivity Reactions to Anticoagulant Drugs
Current Pharmaceutical Design, 2008Drugs with anticoagulant activity, including heparins, hirudins, coumarins, and platelet aggregation inhibitors belong to the most widely used drugs. Hypersensitivity reactions from these agents are rare. However, due to their widespread use, they may have a considerable impact on patient safety and treatment.
Scherer, K. +2 more
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Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs.
Journal of Allergy and Clinical Immunology: In Practice, 2020A. Broyles +54 more
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