Results 91 to 100 of about 146,608 (306)

A protocol to inject ocular drug implants into mouse eyes. [PDF]

STAR Protoc, 2022
Lin CH, Sun YJ, Lee SH, Mujica EM, Kunchur CR, Wu MR, Yang J, Jung YS, Chiang B, Wang S, Mahajan VB.   +10 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

3D Printing Custom Bioactive and Absorbable Surgical Screws, Pins, and Bone Plates for Localized Drug Delivery

Journal of Functional Biomaterials, 2019
Additive manufacturing has great potential for personalized medicine in osseous fixation surgery, including maxillofacial and orthopedic applications.
Karthik Tappa, Udayabhanu Jammalamadaka, Jeffery A. Weisman, David H. Ballard, Dallas D. Wolford, Cecilia Pascual-Garrido, Larry M. Wolford, Pamela K. Woodard, David K. Mills   +8 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Controlled release and biocompatibility of polymer/titania nanotube array system on titanium implants

Bioactive Materials, 2017
Bacterial infection and tissue inflammation are the major causes of early failure of titanium-based orthopedic implants; thus, surgical implants with tunable drug releasing properties represent an appealing way to address some of these problems of ...
Tingting Wang, Zhengyang Weng, Xiangmei Liu, Kelvin W.K. Yeung, Haobo Pan, Shuilin Wu   +5 more
doaj   +1 more source

Analytical and Computational Modeling of Sustained-Release Drug Implants in the Vitreous Humor. [PDF]

J Heat Transfer, 2021
Khoobyar A, Naghdloo A, Penkova AN, Humayun MS, Sadhal SS.   +4 more
europepmc   +1 more source

Trends and Racial/Ethnic Disparities in Antibiotic Prescribing Practices of Dentists in The United States [PDF]

, 2018
Objective The aim of this study was to examine trends and racial/ethnic disparities in antibiotic prescribing practices of dentists in the United States. Methods The US Medical Expenditure Panel Survey data for 1996‐2013 was analyzed.
Okunseri, Christopher, Okunseri, Elaye, Steinmetz, C. N., Szabo, Aniko, Zheng, C.   +4 more
core   +1 more source

Effect of Membrane Exposure on Guided Bone Regeneration: A Systematic Review and Meta‐Analysis [PDF]

, 2018
Aims: This review aimed at investigating the effect of membrane exposure on guided bone regeneration (GBR) outcomes at peri-implant sites and edentulous ridges.
Allen, Annibali, Antoun, Arx, Arx, Arx, Assenza, Bahat, Bartee, Buser, Buser, Buser, Chao, Chiapasco, Chiapasco, Chiapasco, Chin, Cordaro, Cordaro, Cummings, Friedmann, Fu, Gher, Greenstein, Her, Hoffmann, Kfir, Lee, Liberati, Lim, Lindfors, Lizio, Lorenzoni, Lorenzoni, Louis, Lyford, Machtei, Mattout, Mellonig, Meloni, Merli, Misch, Miyamoto, Nowzari, Park, Park, Parodi, Proussaefs, Proussaefs, Proussaefs, Rakhmatia, Seibert, Sethi, Shea, Simion, Simion, Slim, Spray, Tal, Tarnow, Tawil, Torres, Uehara, Urban, Urban, Waasdorp, Wang, Wang, Wang, Wessing, Zitzmann   +70 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source