Results 301 to 310 of about 151,635 (354)
Some of the next articles are maybe not open access.
Implantable Drug-Delivery Systems
Scientific American, 1979Implantable drug-delivery systems are being developed to release drugs to the bloodstream continuously as well as free patients from being hospitalized to receive intravenous infusions or frequent injections. One technique is implantation of a pellet in the subcutaneous tissue so the pellet may be released by erosion.
openaire +2 more sources
2014
Aseptic loosening continues to limit long-term survival of prosthesis implant. The biological pathway leading to osteolysis is not understood completely. Interfacial membranes from clinically failed arthroplasties and in vitro models have demonstrated that macrophages are activated by wear debris and release various potent resorbing mediators.
openaire +1 more source
Aseptic loosening continues to limit long-term survival of prosthesis implant. The biological pathway leading to osteolysis is not understood completely. Interfacial membranes from clinically failed arthroplasties and in vitro models have demonstrated that macrophages are activated by wear debris and release various potent resorbing mediators.
openaire +1 more source
3D printed polymeric drug-eluting implants
International Journal of Pharmaceutics, 2021An extrusion-based 3D printer has been used for the manufacturing of sustained drug release poly(ε-caprolactone) (PCL) implants. Such implants can address issues of reduced patient compliance due to the necessary frequent administration of conventional drug delivery systems, such as tablets, capsules and solutions.
Athina, Liaskoni +2 more
openaire +2 more sources
IMPLANTABLE DRUG DELIVERY SYSTEMS
2022Authors : Dr. GUFRAN AJMAL; Prof. ANUPAMA DIWAN; Dr.
openaire +1 more source
Drug Delivery Systems 4. Implants in Drug Delivery
The Journal of Clinical Pharmacology, 1990In comparison with many of the other drug delivery systems, implantable pumps and implants for variable rate delivery are at a crude stage of development. Although exceptions exist, the typical implantable pump consists of an electromechanically complex mechanism to regulate drug delivery from a percutaneous refillable reservoir, while power to drive ...
openaire +2 more sources
Refillable Intraocular Drug-Eluting Implant
ACS Applied Materials & InterfacesThe increasing incidence of ophthalmic diseases has led the need for multiple dosage regimens, which can cause patient discomfort and noncompliance due to the frequency of medication administration. Still, ophthalmic drug delivery methods, such as eye drops and intravitreal injection, pose challenges, such as poor bioavailability, short half-life, and ...
Hyeonji Kim +5 more
openaire +2 more sources
Miniaturized systems, known as implantable drug delivery systems, are used to administer medicinal medicines to specific sites within the body. They are made of biocompatible substances that enclose the drug payload and control its kinetics of release, enabling sustained delivery.
Jagruti L. Desai +5 more
openaire +1 more source
Jagruti L. Desai +5 more
openaire +1 more source
2015
Implantable drug delivery devices, nondegradable reservoir or biodegradable types, have shown great prospects. These devices have revealed ostensible possibilities of advancement in several applications demanding onerous efforts in controlled and precise, highly localized liberation of decisive doses of drugs with fewer side effects and without direct ...
openaire +1 more source
Implantable drug delivery devices, nondegradable reservoir or biodegradable types, have shown great prospects. These devices have revealed ostensible possibilities of advancement in several applications demanding onerous efforts in controlled and precise, highly localized liberation of decisive doses of drugs with fewer side effects and without direct ...
openaire +1 more source
Implantable Drug Delivery Systems
1998The use of implantable systems for chronic intraspinal delivery of medications has become an important tool in the management of a variety of clinical conditions, includ ing chronic pain due to cancer or nonmalignant causes as well as spasticity of spinal or cerebral origin.
Richard K Osenbach, Kim J Burchiel
openaire +1 more source
Implantable microchips for controlled drug delivery
The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2005We report on the development of an implantable drug delivery system capable of delivering multiple individual doses. This product controls the release of potent therapeutic compounds that might otherwise require frequent injections. The system will provide stable, hermetic storage of therapeutic drugs, such as proteins and peptides, in solid, liquid ...
J M, Maloney, J T, Santini
openaire +2 more sources