Results 221 to 230 of about 2,222,749 (351)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Evaluation of Drug Management Information System to Improve Quality and Users Satisfaction: Case Study at a Primary Health Center

, 2019
Rico Kurniawan, Popy Yuniar, Tris Eryando, Kenji Fadlin Azimi, Retnowati Retnowati, Devi Maryori   +5 more
openalex   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

predicTox: an integrated database of clinical risk frequencies and human gene expression signatures for cardiotoxic drugs. [PDF]

Database (Oxford)
Hansen J, Martinez P, Yadaw AS, Xiong Y, Racz R, Pacanowski MR, Hopkins LL, King NMP, Abernethy D, Sobie E, Iyengar R.   +10 more
europepmc   +1 more source

Application of Hospital Information Intelligent Management System Used in Promoting the Rational Application of Intravenous Drugs for Nurses in Public Health Clinical Center (Preprint)

, 2020
Lina Jiang, Sun Xiao-feng, Cuicui Ji, Daniel P. Griffin   +3 more
openalex   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Therapeutic target database 2026: facilitating targeted therapies and precision medicine. [PDF]

Nucleic Acids Res
Zhang Y, Zhou Y, Xu H, Jiang W, Li B, Lai D, Wan C, Wang S, Zhao M, Tan Y, Lu S, Fan T, Liu X, Zhu F, Chen Y.   +14 more
europepmc   +1 more source

Evaluation of Adverse Drug Events of Remdesivir for the Treatment of COVID-19 in Patients Contacting the 13-Aban Pharmacy Drug and Poison Information Center

Amirhosein Ghahremanian, Hasti Photography, Sona Ghasemi, Mohammadreza Heidari, Elliyeh Ghadrdan   +4 more
openalex   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Gene4Denovo2: an updated platform for human de novo mutations discovery and interpretation. [PDF]

Nucleic Acids Res
Zhu Z, Yu P, Mao X, Liu C, Li K, Zhou Q, Wang Y, Luo T, Xiang X, Zhu Y, Wu D, Jian X, Li B, Tang B, Xia K, Zhao G, Li J.   +16 more
europepmc   +1 more source