Results 231 to 240 of about 21,139,312 (265)

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Peer Recovery Care Planning While Awaiting Alcohol and Other Drug Treatment. [PDF]

Drug Alcohol Rev
Peart A, Roxburgh AD, Findlay L, Veenker B, Shinya T, Manning V, Best D, Lubman DI.   +7 more
europepmc   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

"Once I started going… I had this central wheel hub": Drivers of overdose prevention center engagement and connections to care in Rhode Island. [PDF]

Int J Drug Policy
Dunham K, Walt G, Trombley J, Brothers S, Marshall BDL, Collins AB.   +5 more
europepmc   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Professional Roles and Work-Related Challenges of Anti-Drug Social Workers in Community-Based Drug Rehabilitation: A Systematic Review. [PDF]

Healthcare (Basel)
Jianping W, Jamir Singh PS, Azman A.
europepmc   +1 more source

Review on Major Challenges of Veterinary Service Delivery in Ethiopia. [PDF]

Vet Med Sci
Muhammed A, Wamile M.
europepmc   +1 more source

Consumer Medicines Line closure. [PDF]

Aust Prescr
europepmc   +1 more source

The Detection of Novel Nitazene-Class Opioids in Unregulated Drug Markets in Canada. [PDF]

Drug Alcohol Rev
Gelgoot EA, Scarfone KM, Maghsoudi N, McDonald K, Hao W, Stefan C, Beriault DR, Delaney SR, Ti L, Tobias S, Bowles JM, Werb D, Members of Toronto's Drug Checking Service.   +12 more
europepmc   +1 more source