Results 51 to 60 of about 402,598 (252)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Analysis of Common Causes of Out-of-Specification Results in the Test for Depressor Substances

Shiyan dongwu yu bijiao yixue
According to General Chapter 1145 of Division IV in the Chinese Pharmacopoeia (2020 Edition), the test for depressor substances is a common method for drug testing.
TONG Xiyang, QUE Changtian, ZHANG Feng, ZHAO Lu, WANG Hongping   +4 more
doaj   +1 more source

Pengaruh Kualitas Pelayanan Kefarmasian terhadap Kepuasan Pasien Rawat Inap RSUP Dr. M. Djamil Padang

Jurnal Optimasi Sistem Industri, 2018
Pharmaceutical services at the hospital are an integral part of the hospital's service system. The quality of the pharmacy service affects the hospital's performance as a service company. Pharmacy Installation of Dr. M.
Linda Eka Putri, Dachriyanus, Nilda Tri Putri   +2 more
doaj   +1 more source

The Role and Responsibility of Clinical Pharmacists in Rheumatology Clinic: An exploratory study in Hong Kong

Asia Pacific Journal of Health Management, 2020
In Hong Kong, arthritis is the third leading chronic disorder among the older people. It could create a huge amount of burden on the health care system if patients cannot achieve good diseases control and have recurrent flare up of diseases.
Shirley Wai Ying YIP, Gary Chung Hong Chong   +1 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The importance of drug checking outside the context of nightlife in Slovenia

Harm Reduction Journal, 2018
Background The main purpose of the research was to evaluate the implementation of the drug checking service in Slovenia and to obtain the opinion of users included in harm reduction programmes for high-risk drug users and of drug users in nightlife ...
Matej Sande, Simona Šabić
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

WENDI: A tool for finding non-obvious relationships between compounds and biological properties, genes, diseases and scholarly publications

Journal of Cheminformatics, 2010
Background In recent years, there has been a huge increase in the amount of publicly-available and proprietary information pertinent to drug discovery. However, there is a distinct lack of data mining tools available to harness this information, and in ...
Zhu Qian, Lajiness Michael S, Ding Ying, Wild David J   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Overview, Challenges and Future Prospects of Drug Information Services in Nepal: A Reflective Commentary

Journal of Multidisciplinary Healthcare, 2020
Sunil Shrestha,1,2 Asmita Priyadarshini Khatiwada,2 Sudesh Gyawali,3 P Ravi Shankar,4 Subish Palaian5 1Department of Pharmacy, Nepal Cancer Hospital and Research Center Pvt. Ltd, Lalitpur, Nepal; 2Department of Pharmaceutical and Health Service Research,
Shrestha S, Khatiwada AP, Gyawali S, Shankar PR, Palaian S   +4 more
doaj