Results 91 to 100 of about 257,450 (291)

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuela Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source

Primary Human Tissue Models for Metabolic Dysfunction‐Associated Liver Disease ‐ toward Streamlining Drug Discovery with Patient‐Derived Assays

Advanced Biology, EarlyView.
The review provides a critical up‐to‐date overview of the current landscape of human in vitro models for fatty liver disease, including spheroids, organoids, organ‐on‐a‐chip systems, bioprinted liver constructs and precision‐cut liver slices. Their utility for faithfully modeling different stages of MASLD and MASH are evaluated and their compatibility ...
Sonia Youhanna, Nayere Taebnia, Yingxin Liang, Ningtao Cheng, Yi Wang, Maurice Michel, Volker M. Lauschke   +6 more
wiley   +1 more source

Factors Contributing to Drug Release From Enteric-Coated Omeprazole Capsules: An In Vitro and In Vivo Pharmacokinetic Study and IVIVC Evaluation in Beagle Dogs

Dose-Response, 2020
This study was performed to explore factors influencing the release of the proton pump inhibitor omeprazole from enteric-coated capsules in vitro and absorption in vivo in beagle dogs.
Cheng Cui, Jiabei Sun, Xueqing Wang, Zhenxi Yu, Yaqin Shi   +4 more
doaj   +1 more source

Drug Lag and Associated Factors for Approved Drugs in Korea Compared with the United States. [PDF]

Int J Environ Res Public Health, 2022
Cho I, Han E.
europepmc   +1 more source

Supply-side reduction policy and drug-related harm [PDF]

Large-scale seizures of cocaine, heroin and amphetamine-type substances (ATS) do not result in any reduction in overdoses on these drugs or on arrests for use and possession of these drugs, according to this report.
Don Weatherburn, Grant Sara, Grant Wardlaw, Vasilis Sarafidis, Wai-Yin Wan   +4 more
core   +1 more source

Alcohol Availability and Violence: A Closer Look at Space and Time [PDF]

, 2017
Alcohol availability plays an important role in violence. Less is known about how spatiotemporal patterns of alcohol–violence association vary across time of day and across various crime types. This study examined whether and how the associations between
Snowden, Aleksandra J.
core   +1 more source

Magnetoactive Metamaterials: A State‐of‐the‐Art Review

Advanced Engineering Materials, EarlyView.
Magnetoactive metamaterials combine magnetoactive composites with architected metastructures to enable contactless, tunable control of mechanical, acoustic, and elastic properties. This review highlights recent advances in their design, fabrication, and applications in soft robotics, biomedical devices, and adaptive structures and outlines future ...
Seyyedmohammad Aghamiri, Ramin Sedaghati
wiley   +1 more source

Regulatory efforts to address the access gap for foreign new drugs in China: the priority review program and related policies

Global Health Research and Policy
Background China has implemented the priority review (PR) program and flexible registration requirements for new drugs with significant clinical value since 2016 to accelerate drug access.
Xingyue Zhu, Jinsui Zhang
doaj   +1 more source

The lag time in initiating clinical testing of new drugs in combination with radiation therapy, a significant barrier to progress? [PDF]

, 2014
Philip Blumenfeld, Raphael M. Pfeffer, Zvi Symon, Robert B. Den, Adam P. Dicker, David Raben, Yaacov Richard Lawrence   +6 more
openalex   +1 more source

Deciphering the Origin of Higher Shell Coordination on Single Iron Catalysts for Resilient Modulating Persulfate Oxidation Into Singlet Oxygen Pathway

Advanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
This study reveals that higher shell S coordination can effectively modulate the spin state of FeN4 site via long‐range electronic interactions, giving rise to the oriented generation of singlet oxygen from peroxymonosulfate activation. Abstract Precise manipulation of coordination structure of single‐atom sites and establishment of schematic ...
Liang Zhang, Kai Cheng, Zhizhi Yang, Ye Zhang, Shiro Kubuki, Paul A. Bingham, Yang‐Chun Yong, Bofan Zhang, Xiaoguang Duan   +8 more
wiley   +1 more source