Results 101 to 110 of about 257,450 (291)

A current era in pulsatile drug delivery system: Drug journey based on chronobiology

Heliyon
Almost all biological processes in the human body are regulated by circadian rhythm, which results in drastically different biochemical and physiological conditions throughout a 24 h period.
Amarjitsing Rajput, Prashant Pingale, Darshan Telange, Shubham Musale, Shailesh Chalikwar   +4 more
doaj   +1 more source

Dual‐Mode Film Based on Highly Scattering Nanofibers and Upcycled Chips‐Bags for Year‐Round Thermal Management

Advanced Functional Materials, EarlyView.
Intelligent radiative cooling devices, adaptable to various weather conditions, have the potential for year‐round energy savings. This study introduces a sustainable dual‐mode film made from polycaprolactone nanofibers and upcycled chip bags for effective thermal management.
Qimeng Song, Stefan Rettinger, Chengzhang Xu, Ulrich Mansfeld, Markus Retsch   +4 more
wiley   +1 more source

Clinical data required for the approval of pediatric pharmaceuticals in Japan

BMC Pediatrics
Background In Japan, the number of pharmaceuticals with pediatric indications is low, and some are approved only in Europe or the USA but not in Japan. As the approval review report by the Japanese health authority contains any detailed items considered ...
Hisamitsu Haigo, Kenji Matsuda, Mayumi Shikano   +2 more
doaj   +1 more source

Electroencephalographic effects of ketamine on power, cross-frequency coupling and connectivity in the alpha bandwidth

Frontiers in Systems Neuroscience, 2014
Recent studies of propofol-induced unconsciousness have identified characteristic properties of electroencephalographic alpha rhythms that may be mediated by drug activity at -aminobutyric acid (GABA) receptors in the thalamus.
Stefanie eBlain-Moraes, Uncheol eLee, Seungwoo eKu, GyuJeong eNoh, George A. Mashour   +4 more
doaj   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Overexpression of LAG-3: a potential indicator of low immune function in tuberculosis

Frontiers in Cellular and Infection Microbiology
BackgroundTuberculosis (TB) persists as a global health challenge, with its treatment hampered by the side effects of long-term combination drug therapies and the growing issue of drug resistance.
Yun Pan, Zengxi Yao, Lifen Huang, Meina Xu, Ruichang Chen, Dengsheng Li, Xinyuan Wang, Jianchao Wu, Minran Li, Xujing Liang, Jiaxiong Tan, Jiaxiong Tan   +11 more
doaj   +1 more source

Gastroretentive Pulsatile Release Tablets of Lercanidipine HCl: Development, Statistical Optimization, and In Vitro and In Vivo Evaluation

The Scientific World Journal, 2014
The present study was aimed at the development of gastroretentive floating pulsatile release tablets (FPRTs) of lercanidipine HCl to enhance the bioavailability and treat early morning surge in blood pressure.
Gagganapalli Santhoshi Reddy, Usha Yogendra Nayak, Praful Balavant Deshpande, Srinivas Mutalik   +3 more
doaj   +1 more source

Despite surge in orphan drug designations, approvals still lag [PDF]

, 2011
Monica Heger
openalex   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

HPLC Methods on Drug Analysis. Mantu K. Ghosh. Berlin: Springer-Ver-lag, 1992, 585 pp. $138.00. ISBN 3-53824-0 [PDF]

, 1993
Robert L. Fitzgerald
openalex   +1 more source