Drug lag and associated factors of orphan drugs approved by the U.S. in China. [PDF]
Front PharmacolMo Q, He J, Guo Q, Yang Y.
europepmc +3 more sources
Pulsatile Chronotherapeutic Drug Delivery for Controlling Early Morning Surge in Blood Pressure; Effect of Coating on Eplerenone In-vitro, In-vivo Release and Urinary Na/K Ratio [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2022 The objective of the present study was to develop time delayed chronotherapeutic formulation of Eplerenone (Ep) to provide rapid drug release after a pre-determined lag time for the treatment of early morning hypertension.
Maha Abd El hameed Marzouk +3 more
doaj +1 more source
Review time of oncology drugs and its underlying factors: an exploration in China
Frontiers in Pharmacology, 2023 Introduction: How the launch delay of drugs and other factors of interest can influence the length of the review period by drug agencies is still unknown, and understanding this can help better strike the trade-off related to review speed.Methods: We ...
Xingyue Zhu, Bao Liu
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Trends in oncology drug lags in Japan from 2001 to 2020: A cross‐sectional study
Clinical and Translational Science, 2023 Anticancer drugs are essential in the treatment of serious diseases, but their applications are limited by drug lags. This study investigated the characteristics of anticancer drugs approved in Japan over the past 20 years and compared the drug lag ...
Hideki Maeda +5 more
doaj +1 more source
Development of a high-throughput TR-FRET screening assay for LAG-3/FGL1 interaction
SLAS Discovery, 2023 Lymphocyte activation gene 3 (LAG-3) is a negative immune checkpoint and a key regulator of immune homeostasis with multiple biological activities related to T-cell functions.
Somaya A. Abdel-Rahman +2 more
doaj +1 more source
PD-1/LAG-3 bispecific antibody potentiates T cell activation and increases antitumor efficacy
Frontiers in Immunology, 2022 Several clinical studies demonstrate that there exist other immune checkpoints overexpressed in some PD-1 inhibitor-resistant tumor patients. Among them, Lymphocyte-activation gene 3 (LAG-3) is one of the important immune checkpoint molecules and has ...
Ning Shi +17 more
doaj +1 more source
A Pulsatile Tablet of Famotidine Using Core in Cup Method.
Journal of Pharmacy, 2023 Introduction: The present work aims to formulate pulsatile delivery system using “core-in-cup” system for Famotidine, a H2 receptor antagonist used for duodenal ulcer, benign gastric ulcers, GERD and nocturnal acid breakthrough (A physiological ...
Shreya Ajay Rajguru +5 more
doaj +1 more source
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023 Superporouse hydrogel (SPH) is widely used and investigated as a gastro retentive drug delivery system to extend drug residence time in the stomach However, their mechanical strength represents a problem because they need to withstand the ...
Safa Mohammed Nser +1 more
doaj +1 more source
Early phase pharmacokinetics but not pharmacodynamics are influenced by propofol infusion rate [PDF]
, 2009 Background: Conventional compartmental pharmacokinetic models wrongly assume instantaneous drug mixing in the central compartment, resulting in a flawed prediction of drug disposition for the first minutes, and the flaw affects pharmacodynamic modeling ...
Hagihira, Satoshi +5 more
core +2 more sources
Optimization of Chitosan and Cellulose Acetate Phthalate Controlled Delivery of Methylprednisolone for Treatment of Inflammatory Bowel Disease [PDF]
Advanced Pharmaceutical Bulletin, 2017 Purpose: Inflammatory bowel disease (IBD) is a chronic, relapsing and often life-long disorder. The best way to tackle IBD is to develop a site targeted drug delivery. Methylprednisolone is a potent anti-inflammatory steroid.
Swati Jagdale, Apoorva Chandekar
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