Results 191 to 200 of about 257,450 (291)

A Guide to Time lag and Time lag Shortening Strategies in Oncology-Based Drug Development

, 2017
Berna Uygur, Josh Duberman, Steven M. Ferguson   +2 more
openalex   +1 more source

Highland Falls, Village of and Highland Falls Patrolmens Benevolent Association, PBA (2001) [PDF]

, 2001

core   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il. Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Impact of oil and gas boom and busts on working-age mortality in the U.S. [PDF]

Environ Epidemiol
Thombs RP, Willis MD.
europepmc   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Phenotypic and targeted drug discovery in immune therapeutics: challenges, opportunities, and future directions. [PDF]

RSC Adv
Vázquez NG, Nada H, Upadhyay S, Gabr MT.   +3 more
europepmc   +1 more source

Electron–Matter Interactions During Electron Beam Nanopatterning

Advanced Functional Materials, EarlyView.
This article reviews the electron–matter interactions important to nanopatterning with electron beam lithography (EBL). Electron–matter interactions, including secondary electron generation routes, polymer radiolysis, and electron beam induced charging, are discussed.
Camila Faccini de Lima, Prathiba Thamizhavel, Taylor J. Woehl   +2 more
wiley   +1 more source

Novel anti-LAG-3 antibody LBL-007 with anti-PD-1 blockade enhances antitumor immunity by promoting T cell-induced apoptosis. [PDF]

Sci Rep
Qin K, Zhou H, Yu X, Liu J, Wu C, Zhang C, Zhou L.   +6 more
europepmc   +1 more source

Multipurpose Transparent Nanocomposites for Gamma Spectroscopy, Pulse Shape Discrimination, Thermal Neutron Detection, Radiation Shielding, and High Refractive Index Applications

Advanced Functional Materials, EarlyView.
Materials exist that are useful for gamma scintillation, radiation shielding, neutron‐gamma pulse shape discrimination (PSD), thermal neutron detection, or high refractive index applications. While certain materials have exhibited optimal performance for each of these applications, none achieve multiple functions.
Isabelle Winardi, Stephane Miaule, Robert Carmichael, Bowen Sun, Ziqing Han, Prabhav Surabhi, Zhen Luo, Noelan Hum, David Prout, Yi‐An Chen, Ting‐Hsuan Wu, Hao Yu, Arion Chatziioannou, Qibing Pei   +13 more
wiley   +1 more source

Clinically applicable parasite viability assay for rapid assessment of antimalarial pharmacodynamic endpoints. [PDF]

Antimicrob Agents Chemother
Maiga M, Wicha SG, Diallo F, Traoré I, Samaké AK, Sogore F, Diakité O, Dao F, Diallo D, Traoré A, Djimde AA, Spangenberg T, Demarta-Gatsi C, Dembele L.   +13 more
europepmc   +1 more source