Results 41 to 50 of about 4,177,143 (225)

Design and in vitro characterization of novel pulsatile delivery system of biguanide antidiabetic drug

Journal of Pharmacy and Bioallied Sciences, 2020
Aim: This work shows the development of pulsatile capsular pellets of metformin hydrochloride and its characterisation. Material and Methods: The novel drug delivery system consisted of hydroxy propyl cellulose Type H.
Rahul Pandey, William Selvamurthy
doaj   +1 more source

Bridging the new drug access gap between China and the United States and its related policies

Frontiers in Pharmacology
Introduction: The access gap for novel pharmaceuticals between China and the developed countries is a major public health issue in China. It is crucial to understand the determinants of this gap to ensure timely access to new drugs and enhance patient ...
Xingyue Zhu, Yang Chen
doaj   +1 more source

International comparison of availability for orphan drugs: focused on approved orphan drugs in South Korea

Journal of Pharmaceutical Policy and Practice
Introduction: In this study, we aimed to comparatively analyse the indicators of availability to orphan drugs in South Korea, the United States of America, Europe Union, and Japan.Methods: For 169 drugs designated as orphan drugs in South Korea between ...
Eun Young Shin, Young Jun Hong, Kyung Min Lim, Tae Hyang Kim, Jong Hyuk Lee   +4 more
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Lag times in the publication of network meta-analyses: a survey

BMJ Open, 2021
Objective We assessed the extent of lag times in the publication and indexing of network meta-analyses (NMAs).Study design This was a survey of published NMAs on drug interventions.Setting NMAs indexed in PubMed (searches updated in May 2020).Primary and
Fernando Fernandez-Llimos, Fernanda S Tonin, Ariane G Araujo, Mariana M Fachi, Vinicius L Ferreira, Roberto Pontarolo   +5 more
doaj   +1 more source

Availability and drug lag of new medicines in South Korea

European Journal of Public Health, 2019
This study aims to capture the availability of new medicines, to measure drug lags for new medicines, and to demonstrate various factors affecting timely availability of new medicines in Korean market.
K. Son
semanticscholar   +1 more source

Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization

Drug Delivery, 2022
Pulsatile drug delivery systems have drawn attention in contemporary research for designing chronotherapeutic systems. The current work aims to design pulsatile ketorolac tromethamine tablets using compression coating for delayed delivery with a lag time
Hibah M. Aldawsari, N. Raghavendra Naveen, Nabil A. Alhakamy, Prakash S. Goudanavar, GSN Koteswara Rao, Roja Rani Budha, Anroop B. Nair, Shaimaa M. Badr-Eldin   +7 more
doaj   +1 more source

The immune checkpoint expression in the tumor immune microenvironment of DLBCL: Clinicopathologic features and prognosis

Frontiers in Oncology, 2022
Background & aimsThe immune checkpoint recently provides a new strategy for the immunotherapy of malignant tumors. However, the role in the immune microenvironment of DLBCL is not completely clear.MethodsWe detected the expression of PD-1, LAG-3, TIM-
Jiajia Ma, Xuelian Pang, Junna Li, Wei Zhang, Wenli Cui   +4 more
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Cutting-Edge: Preclinical and Clinical Development of the First Approved Lag-3 Inhibitor

Cells, 2022
Immune checkpoint inhibitors (ICIs) have revolutionized medical practice in oncology since the FDA approval of the first ICI 11 years ago. In light of this, Lymphocyte-Activation Gene 3 (LAG-3) is one of the most important next-generation immune ...
Luisa Chocarro, Ana Bocanegra, Ester Blanco, Leticia Fernández-Rubio, Hugo Arasanz, Miriam Echaide, Maider Garnica, Pablo Ramos, Sergio Piñeiro-Hermida, Ruth Vera, David Escors, Grazyna Kochan   +11 more
doaj   +1 more source

Semisolid matrix-filled hard gelatin capsules for rapid dissolution of amlodipine besilate: Development and assessment

Journal of Advanced Pharmaceutical Technology & Research, 2013
The objective of the study was to prepare semisolid capsules (SSCs) of poorly water-soluble drug amlodipine besilate (AB) using a combination of technologies involving solid dispersion (SD) preparation and converting it into semisolid matrix filled in ...
Vijay K Tyagi, Deshvir Singh, Kamla Pathak   +2 more
doaj   +1 more source

Aceclofenac loaded microspheres: Formulation and evaluation of novel preprogrammed drug delivery for the treatment of arthritis

Intelligent Pharmacy
Arthritis is a widespread joint disorder globally, the patient completely dependent on NSAIDs which are administered after a fixed interval to subside the pain.
Hema Jaiswal, Mohammad Tahir Ansari, Tarique Mahmood, Farogh Ahsan, Vaseem Ahamad Ansari, Usama Ahmad   +5 more
doaj   +1 more source