Results 51 to 60 of about 4,177,143 (225)

Chronomodulated drug delivery system of Irbesartan: Formulation and development using Desing of Experiment (DoE)

open access: yesBulletin of Faculty of Pharmacy Cairo University, 2018
The work is based on pulsatile principles to deliver a programmed dose of Irbesartan, an angiotensin-II receptor antagonist for chronotherapy of hypertension induced by excessive secretion of aldosterone, thereby lower the blood pressure at early morning.
Komal Parmar   +2 more
doaj   +1 more source

Floating tablets of minocycline hydrochloride: Formulation, in-vitro evaluation and optimization

open access: yesFuture Journal of Pharmaceutical Sciences, 2017
Current study was aimed to formulate gastroretentive floating tablets of minocycline hydrochloride with desired floating properties, desired drug release rate, its local action in stomach for treatment of H.
Ali Raza   +4 more
doaj   +1 more source

Japan lags behind the UK in neurological drug approvals [PDF]

open access: yesBritish Journal of Clinical Pharmacology, 2011
Many drugs that are available in the overseas market have not yet been approved by the Ministry of Health, Labour and Welfare (MHLW) in Japan. A study of the top 100 drugs by sales in 2004 shows a 2.5-year gap between the launch dates in the UK/US and Japan [1].
Rumiko, Shimazawa, Masayuki, Ikeda
openaire   +2 more sources

Preparation and evaluation of rotigotine-loaded implant for the treatment of Parkinson’s disease and its evolution study

open access: yesSaudi Pharmaceutical Journal, 2016
Purpose: To develop rotigotine-loaded implants (RI) to achieve continuous release of rotigotine for long duration for the treatment of Parkinson’s disease (PD). Methods: RI was prepared by hot-melt extrusion method using poly (lactide-co-glycolide) (PLGA)
Aiping Wang   +6 more
doaj   +1 more source

Anticancer drug development from traditional cytotoxic to targeted therapies: evidence of shorter drug research and development time, and shorter drug lag in Japan

open access: yesJournal of Clinical Pharmacy and Therapeutics, 2012
What is known and Objective:  Concern about the drug lag, the delay in marketing approval between one country and another, for anticancer drugs has increased in Japan.
E. Kawabata-Shoda   +3 more
semanticscholar   +1 more source

DRUG LAG FOR ANTIMICROBIAL AGENTS: COMPARISON OF THE US, EU AND INDIA APPROVALS

open access: yesNational Journal of Medical Research, 2012
Background: Antimicrobial resistance is a global problem and the need for new antimicrobial agents is greater in both developed and developing nations.
Bhaven C Kataria   +2 more
doaj  

Development and evaluation of time controlled release tablet of ketoprofen for the treatment of Rheumatoid Arthritis

open access: yesJournal of Applied Pharmaceutical Research, 2017
The aim of present study was to develop and evaluate time controlled release tablet of Ketoprofen intended for rheumatoid arthritis. The cardinal sign of rheumatoid arthritis are stiffness, swelling and pain of one or more joints of the body ...
P H Sharma, J. G. Avari
doaj   +1 more source

A Significant Anticancer Drug Approval Lag Between Japan and the United States Still Exists for Minor Cancers

open access: yesClinical pharmacology and therapy, 2018
Reports have indicated that approval lag for anticancer drugs between Japan and the United States has decreased. However, if this is also true for drugs used to treat minor cancers remains unknown.
Kenji Yamashita, M. Kaneko, M. Narukawa
semanticscholar   +1 more source

Therapeutic potential of targeting LAG-3 in cancer

open access: yesJournal for ImmunoTherapy of Cancer
Immune checkpoint inhibitors targeting negative regulatory checkpoints including programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein 4 have produced significant improvements in progression-free survival (PFS) and overall survival in ...
Diwakar Davar   +2 more
doaj   +1 more source

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