Results 91 to 100 of about 1,066,064 (314)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Nonsteroidal anti-inflammatory drug-exacerbated respiratory disease: diagnosis and current management [PDF]
, 2023 Kamran Imam, Katharine M. Woessner
openalex +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
A computer architecture based on disruptive information technologies for drug management in hospitals. [PDF]
PeerJ Comput Sci, 2023 Chalmeta R +2 more
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Patient Preference and AdherenceZhitong Zhang,1 Xiuli Bai,2 Le Hao,3 Yanli Wang2 1School of Nursing, Inner Mongolia Medical University, Hohhot, Inner Mongolia, People’s Republic of China; 2Department of Nursing, Inner Mongolia People’s Hospital, Hohhot, Inner Mongolia, People’s ...
Zhang Z, Bai X, Hao L, Wang Y
doaj
ToxicsMicroplastic and nanoplastic (MNP) particles have been observed in various human organs. However, polypropylene (PP), one of the top three most commonly detected types of MNPs in terms of quantity, is also present in injections given for the infusion ...
Jie Wang +5 more
doaj +1 more source
Development of a Drug Management Performance Application: A Needs Assessment in Indonesia. [PDF]
Healthc Inform Res, 2023 Faradiba, Satibi, Lazuardi L.
europepmc +1 more source