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"Before medically advised" departure from hospital and subsequent drug overdose: a population-based cohort study. [PDF]

open access: yesCMAJ
Khan M   +8 more
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Drug overdose in children

Journal of Paediatrics and Child Health, 1985
AbstractThis paper reviews epidemiological factors, drugs taken, management and outcome of 478 children admitted to the Royal Children's Hospital with drug poisoning during the 5 years 1978‐82. Accidental ingestion in young children is still common whilst self poisoning is increasing in the age group 8‐17 years.
J, Tibballs, E J, McArdle, T C, Brown
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Pharmacokinetics of Drug Overdose

Clinical Pharmacokinetics, 1981
Pharmacokinetics of drugs taken in overdose may differ from those observed following therapeutic doses. Differences are due both to dose-dependent changes and to effects of drugs or pathophysiological consequences of the overdose on kinetics. Dose-dependent changes in rate and extent of absorption, bioavailability (saturation of first-pass metabolism),
J, Rosenberg, N L, Benowitz, S, Pond
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Pharmacokinetics of Drugs in Overdose

Clinical Pharmacokinetics, 1992
The pharmacokinetics of drugs may be altered following an overdose. The degree of absorption depends on the physical characteristics of the drug; the rate of dissolution may delay or broaden peak serum concentrations. The pathophysiological effects of a drug may also limit or augment absorption.
Y J, Sue, M, Shannon
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