Results 311 to 320 of about 3,856,896 (414)

Treatment Experience Using a Micro‐Induction Buprenorphine Protocol for Chronic Pain in Pediatric Sickle Cell Disease

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with sickle cell disease (SCD) experience painful vaso‐occlusive episodes that increase with age; a subset develops chronic pain (CP). CP is usually managed with acute pain management guidelines despite evidence of ineffectiveness.
Ashwin Patel   +6 more
wiley   +1 more source

On the Role of Genetic Testing for Personalized Drug Overdose Management

open access: green, 2013
Alex F. Manini   +3 more
openalex   +2 more sources

Pharmacotherapy research landscape and knowledge gaps of opioids in maternal and pediatric populations

open access: yesPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.
Abstract The use and misuse of opioids has surged in the past decade, with nearly half of the users being female. Although opioid use is lower among pregnant women, trends mirror the general population. While pediatric exposures largely occur through prescriptions.
Aditi Shendre   +20 more
wiley   +1 more source

Pharmacotherapy for Cirrhosis in Japan

open access: yesPortal Hypertension &Cirrhosis, EarlyView.
As cirrhosis progresses from the compensated to the decompensated stage, liver disease‐related events such as varices, ascites, encephalopathy, sarcopenia, jaundice, and bleeding tendency, as well as liver carcinogenesis, can occur at a high rate. With the advent of new pharmacotherapies for cirrhosis in the last decade, liver fibrosis has been shown ...
Hiroki Nishikawa, Soo Ki Kim, Akira Asai
wiley   +1 more source

Deep learning (DL)‐based advancements in prostate cancer imaging: Artificial intelligence (AI)‐based segmentation of 68Ga‐PSMSA PET for tumor volume assessment

open access: yesPrecision Radiation Oncology, EarlyView.
This review highlights the use of 68Ga‐PSMA PET in prostate cancer (PC) for tumor volume quantification, crucial for staging, treatment planning, and prognosis. Traditional manual segmentation methods are time‐consuming and variable, while AI‐based segmentation techniques, particularly deep learning models like convolutional neural networks, offer ...
Sharjeel Usmani   +6 more
wiley   +1 more source

Quantitative Systems Toxicology Modeling of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended‐Release and Immediate‐Release Formulations in Adults With Chronic Alcohol Use or Low Glutathione

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Acetaminophen (APAP), an over‐the‐counter analgesic and antipyretic, can cause hepatotoxicity when ingested in large overdoses. APAP has multiple formulations including immediate‐release (IR) and extended‐release (ER) preparations. A recently published consensus statement on the management of APAP poisoning indicated that management of APAP‐ER
Kyunghee Yang   +8 more
wiley   +1 more source

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