Results 81 to 90 of about 235,245 (306)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Behavioral Dynamics in Drug Tourism: The Interplay of Packaging, Attitudes, Behavioral Intention, and the Moderating role of Anti-Drug Information

SAGE Open
The primary objective of this research is to examine the behavioral characteristics of tourists engaging in drug tourism, which is defined here as traveling to destinations where drug use is legal.
Jimin Shim, Won Seok Lee, Joonho Moon
doaj   +1 more source

Cost Analysis of Various Antiglaucoma Drugs Available in India

Delhi Journal of Ophthalmology
Purpose: To do the comprehensive cost analysis of various anti-glaucoma drugs available in the Indian market, comparing the effective cost per drop across different brands and classes of medications to guide rational prescription practices. Study Design:
Siddharth Siddharth, Manav Deep Singh, Varsha Negi   +2 more
doaj   +1 more source

Post-dispensing stability surveillance: Stavudine

African Journal of Primary Health Care & Family Medicine, 2009
Background: Stavudine, a thymidine nucleoside, is a reverse transcriptase inhibitor, which is extensively used in the treatment of HIV infected patients.
Kamsaladevi K. Naidoo, Thavendran Govender, Rellissa A. Deonunan, Terusha Govender, Calveni Naidoo, Ramona Moodley, Melissa Govender, Khahliso P. Miya   +7 more
doaj   +1 more source

Comparative study of design: application to Engineering Design [PDF]

, 2005
A recent exploratory study examines design processes across domains and compares them. This is achieved through a series of interdisciplinary, participative workshops.
Blackwell, A., Bucciarelli, L., Clarkson, P. J., Earl, C., Eckert, C., Knight, T., Macmillan, S., Stacey, M., Whitney, D.   +8 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Phytochemical analysis and biological study on Sinapis alba L. seeds extract incorporated with metal nanoparticles, in vitro approach

Scientific Reports
White mustard (Sinapis alba L.) seeds are the most commonly used mustard species in herbal medicine to treat a wide range of inflammatory disorders. Due to its increased bioavailability and lower toxicity, the green biosynthesis of metal nanoparticles (M-
Wael Mahmoud Aboulthana, Amal M. El-Feky, Noha El-Sayed Ibrahim, Ahmed A. F. Soliman, Ahmed Mahmoud Youssef   +4 more
doaj   +1 more source

Screening for the optimal siRNA targeting a novel gene (HA117) and construction and evaluation of a derivative recombinant adenovirus [PDF]

, 2010
We found a novel gene named as HA117 in our previous research. At this study, we screened for an optimal siRNA targeting the novel gene HA117 using the pSOS-HUS method, verified the results of pSOS-HUS siRNA screening for optimal affinity for the target ...
Gaihuan Zheng, Qing Luo, Xianqing Jin, Youhua Xu, Yuxia Guo   +4 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Removal of the nonconformities in the drug boxes packaging industry

MATEC Web of Conferences, 2017
The paper presents the specific quality aspects of cardboard drug boxes (folding boxes) used as packaging in pharmaceutical industry. The types of defects and nonconformities that occur during offset printing and finishing of the packaging products are ...
Bălan Emilia, Dobrea Florin Marian
doaj   +1 more source