Results 41 to 50 of about 7,344,621 (307)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Residents’ preferences for inclusive commercial supplementary medical insurance: a discrete choice experiment

Health Economics Review
Background In China, inclusive commercial supplementary medical insurance (ICSMI) has developed rapidly, and the size of the insured population is critical for its long-term sustainability.
Yeyi Feng, Gaojie Li, Shumin Wu, Qingran Sun, Xiaoyu Xi, Ennan Wang   +5 more
doaj   +1 more source

Illusions Clouding Decision-Making: How the Justice System Fails to Understand the Illicit Drug Market

Journal of Illicit Economies and Development, 2019
This paper reviews some of the main research on drug law enforcement in Brazil since the 2006 Drug Law came into force, noting a clear and constant pattern of police and judicial focus directed at retail drug trafficking, decisively impacting current ...
Luiz Guilherme Mendes de Paiva, Juliana de Oliveira Carlos   +1 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

IDPC drug policy guide. [PDF]

, 2016
The IDPC Drug Policy Guide brings together global evidence, best practice and experiences to provide expert analysis across the spectrum of drug policy. Each chapter of the Guide introduces a specific policy challenge or principle, and presents advice

core  

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

The mediating role of health-related behaviors between social capital and primary healthcare physicians’ health-related quality of life

Scientific Reports
This study aimed to evaluate the correlation between social capital and physicians’ health-related quality of life(HRQoL) in primary healthcare institutions. Simultaneously, we examined the mediating role of health-related behaviors in the process.
Zonghao Wu, Zhuoqi Gu, Yukun Wei, Yuankai Huang, Ennan Wang   +4 more
doaj   +1 more source

Criminal justice drug policy in Ireland: policy paper 1. [PDF]

, 2007
This paper outlines the need in Ireland for a review of the effectiveness of criminal justice drug policy. It will define what constitutes criminal justice drug policy and proposes key principles and specific recommendations to guide in the development ...
O'Mahony, Paul, Cassin, Sean
core  

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Vascular Disease, Non‐Steroidal Anti‐Inflammatory Drugs and Risk of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives A history of vascular disease has been shown to be associated with an increased risk of Parkinson's disease, but this may be due to reverse causation. In addition, non‐steroidal anti‐inflammatory drugs are thought to reduce Parkinson's disease risk, but evidence is inconsistent and confounding by prior vascular disease is possible ...
Clare Wotton, Carol Hermon, Sarah Floud, Gillian Reeves, Isobel Barnes   +4 more
wiley   +1 more source