Results 211 to 220 of about 40,019 (337)

Telemedicine-supported penicillin allergy delabeling in low-risk patients. [PDF]

Mhealth
Smolinska S, Boccabella C, Bouza TR, Jurkiewicz K, Popescu FD.   +4 more
europepmc   +1 more source

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

Knowledge and Awareness of Drug-Induced Hypersensitivity Reactions Among Nurses and Pharmacists: A Cross-Sectional Study. [PDF]

Cureus
Altowayan WM, Alqasoumi A, Mohana AI, Alsowinea A, Alkathlan MS, Nheet TS, Alharbi TA, Alaidah A, Alharbi FM, ALRashidi AM, Alkhalawi KA.   +10 more
europepmc   +1 more source

Drug Provocation Tests in the Diagnosis of Hypersensitivity Reactions to Non-Steroidal Anti-Inflamatory Drugs in Children [PDF]

, 2013
María Angeles Zambonino, Marı́a José Torres, Candelaria Muñoz, Gloria Requena, Cristobalina Mayorga, Teresa Posadas, Antonio Urda, Miguel Blanca, Jose Luis Corzo Higueras   +8 more
openalex   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

ECG Markers of Positive Drug Challenge With Ajmaline in Patients With Brugada Syndrome. [PDF]

Ann Noninvasive Electrocardiol
Tülümen E, Kruska M, Wuerfel S, Kohl M, Liebe V, Akin I, Kuschyk J, Duerschmied D, Borggrefe M, Rudic B.   +9 more
europepmc   +1 more source

Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion

Advanced Science, EarlyView.
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab, Rasika Daware, Marcelo A. Szymanski de Toledo, Oskar Weber, Dimitris Kapsokalyvas, Twan Lammers, Horst Fischer, Federica De Lorenzi, Fabian Kiessling   +8 more
wiley   +1 more source

Low-dose oral flecainide provocation test for Brugada syndrome: a case series. [PDF]

Egypt Heart J
Nguyen Thanh X, Ngoc Tran T, Nguyen Van T, Nguyen Duc N, Pham Ngoc T, Nguyen Thi H, Nguyen Van H, Nguyen Van L.   +7 more
europepmc   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source