Results 41 to 50 of about 8,652,406 (249)

Antibiotic Allergy De-Labeling: A Pathway against Antibiotic Resistance

Antibiotics, 2022
Antibiotics are one of the most frequently prescribed drugs. Unfortunately, they also are the most common cause for self-reported drug allergy, limiting the use of effective therapies.
Inmaculada Doña, Marina Labella, Gádor Bogas, Rocío Sáenz de Santa María, María Salas, Adriana Ariza, María José Torres   +6 more
doaj   +1 more source

Flare-up of previously negative patch test and intradermal test with amoxicillin after oral provocation

, 2018
Flare-up reactivity was first described in 1981 in patients with nickel contact eczema as a reactivation of former contact allergy and/or patch test reaction sites because of systemic metal exposure.
Daniela Agostinelli, Luca Stingeni, Tramontana, Marta, Hansel, Katharina, Leonardo Bianchi, Agostinelli, Daniela, Marta Tramontana, Stingeni, Luca, Katharina Hansel, Bianchi, Leonardo   +9 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Immediate hypersensitivity reactions to iodinated contrast media: The diagnosis of allergy by skin testing

Clinical and Translational Allergy, 2022
Among 74 patients with an immediate hypersensitivity reaction (IHR) to iodinated contrast media (ICM), the rate of allergic patients confirmed by positive prick test or diluted intradermal test (IDT) was 8.1%. 12.5% of re‐exposed patients had a recurrent
Juliette Caron, Sahara Graf, Christine Delebarre‐Sauvage   +2 more
doaj   +1 more source

Approach for delabeling beta-lactam allergy in children

Frontiers in Allergy, 2023
A considerable number of pediatric patients treated with beta-lactam (BL) antibiotics develop delayed onset of skin rashes during the course of treatment.
R. Sáenz de Santa María, R. Sáenz de Santa María, G. Bogas, G. Bogas, M. Labella, M. Labella, A. Ariza, M. Salas, M. Salas, I. Doña, I. Doña, M. J. Torres, M. J. Torres, M. J. Torres, M. J. Torres   +14 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The negative predictive value of 5-day drug provocation test in nonimmediate beta-lactam allergy in children

, 2020
WOS: 000531553000017PubMed ID: 31923549Background Extending the drug provocation test (DPT) period is recommended for patients with suspected nonimmediate beta-lactam antibiotic (BLA) allergy and negative DPT. No consensus has been reached regarding the
Toyran, Müge, Dibek Mısırlıoğlu, Emine, Hakan Guvenir, Güvenir, Hakan, Ilknur Kulhas Celik, Civelek, Ersoy, Hurmuzlu, Selen, Kulhas Çelik, İlknur, Muge Toyran, Ersoy Civelek, Can Naci Kocabas, Selen Hurmuzlu, Emine Dibek Misirlioglu, Kocabaş, Can Naci, Misirlioglu, Emine Dibek, Celik, Ilknur Kulhas   +15 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Fixed drug eruption due to clarithromycin

Journal of Research in Pharmacy Practice, 2013
Fixed drug eruption (FDE) is an unusual adverse effect of any drug, especially antibiotics like clarithromycin. Herein we report a case of clarithromycin induced FDE in a 30-year-old man who presented with recurrent erythematous and pruritic cutaneous ...
Santoshi Balkrishna Malkarnekar, L Naveen   +1 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source