Results 51 to 60 of about 9,770,479 (402)

DRESS Syndrome: An Unusual Side Effect [PDF]

Journal of Clinical and Diagnostic Research, 2019
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is often an overlooked entity manifesting as fatal hypersensitivity response associated with use of aromatic anti-epileptic drugs.
Kapil Bhalla, Sanjiv Nanda, Ashish Gupta, Deepak Nehra, Shuchi Mehra   +4 more
doaj   +1 more source

Signalling paediatric side effects using an ensemble of simple study designs [PDF]

, 2014
Background: Children are frequently prescribed medication `o-label', meaning there has not been sucient testing of the medication to determine its safety or eectiveness.
Aickelin, U., Aickelin, U., Garibaldi, J.M., Garibaldi, J.M., Gibson, J.E., Gibson, J.E., Hubbard, R.B., Hubbard, R.B., Reps, J.M., Reps, J.M., Soria, D., Soria, D.   +11 more
core   +6 more sources

Improved Network Performance via Antagonism: From Synthetic Rescues to Multi-drug Combinations [PDF]

, 2010
Recent research shows that a faulty or sub-optimally operating metabolic network can often be rescued by the targeted removal of enzyme-coding genes--the exact opposite of what traditional gene therapy would suggest.
Adilson E. Motter, Baba, Blagosklonny, Bollenbach, Bourgeois, Burgard, Burgard, Cagatay, Chait, Cun, Dancey, Duarte, Edwards, Feist, Fischer, Fong, Fong, Fong, Fong, Fraenkel, Gerdes, Giaever, Goebl, Harrison, Hashimoto, Hegreness, Henry, Herring, Hilgetag, Hilgetag, Hillenmeyer, Hopkins, Huttenlocher, Huttenlocher, Isalan, Kauffman, Keiser, Kim, Kitano, Kupiec, Ma, Miller, Motter, Motter, Nishikawa, Olson, Palsson, Papp, Pharkya, Reguly, Segre, Segre, Shlomi, Timmermans, Wagner, Yeh, Yildirim, Yngvadottir, Zamboni   +58 more
core   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Cutaneous adverse drug reactions in a tertiary teaching hospital: A prospective, observational study

Indian Journal of Dermatology, 2021
Objective: To describe clinical patterns, identify associated drugs, and perform causality assessment of cutaneous adverse drug reactions. Materials and Methods: In this prospective, observational study, patients with signs of cutaneous drug reaction ...
Anuja Jadhav, Sharmila Patil, Isheeta Manchanda, Ruchita Hasija, Anant Patil   +4 more
doaj   +1 more source

A two-phase two-layer model for transdermal drug delivery and percutaneous absorption

, 2014
One of the promising frontiers of bioengineering is the controlled release of a therapeuticdrug from a vehicle across the skin (transdermal drug delivery).
de Monte, Filippo, Pontrelli, Giuseppe
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

New Insights into Drug Reaction with Eosinophilia and Systemic Symptoms Pathophysiology

Frontiers in Medicine, 2017
Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome, is a severe type of cutaneous drug-induced eruption.
P. Musette, B. Janela
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Case Report: Positive Outcome of a Suspected Drug-Associated (Immune Mediated) Reaction in a 4-Year-Old Male French Bulldog

Frontiers in Veterinary Science, 2021
Toxic epidermal necrolysis (TEN) is a rare and severe life-threatening syndrome characterized by apoptosis of keratinocytes resulting in devitalization of the epidermis affecting more than 30% of skin surface.
Line-Alice Lecru, Daniel Combarros, Daniel Combarros, Eloy Castilla-Castaño, Maxence Delverdier, Maxence Delverdier, Marie-Christine Cadiergues, Marie-Christine Cadiergues, Charline Pressanti, Charline Pressanti   +9 more
doaj   +1 more source