Results 161 to 170 of about 3,939,397 (309)

Catheter-Deliverable Floating Hydrogels for Sustained Intravesical Drug Release. [PDF]

Gels
Li J, Ni C, Li S, Huang Y, Yue J.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Drug Release via Ultrasound-Activated Nanocarriers for Cancer Treatment: A Review

Conventional cancer chemotherapy often struggles with safely and effectively delivering anticancer therapeutics to target tissues, frequently leading to dose-limiting toxicity and suboptimal therapeutic outcomes.
Husseini, Ghaleb, Husseini, Ghaleb A., Khaled Armouch Al Refaai, Ghaleb A. Husseini, Abuwatfa, Waad, Waad Abuwatfa, AlSawaftah, Nour, Al Refaai, Khaled Armouch, Nour A. AlSawaftah, AlSawaftah, Nour A.   +9 more
core   +1 more source

Development and characterization of aceclofenac-LDH/alginate porous microspheres for pH-responsive drug release. [PDF]

RSC Adv
Chen Y, Wu X.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Electrosprayed Shellac-Salt Nanoparticles for Improved Intestinal Dissolution and pH-Responsive Drug Release. [PDF]

ACS Omega
Krongrawa W, Limmatvapirat C, Sriamornsak P, Chinatangkul N, Chansatidkosol S, Limmatvapirat S.   +5 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Linker Design in Antibody-Drug Conjugates: Balancing Stability and Drug Release. [PDF]

Pharmaceutics
Albino SN, Domingos MM, Pacheco TR, Carvalho AS, Castanho MARB, Cavaco M.   +5 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Poloxamer/HPMC/Carbopol-Based Thermosensitive Hydrogel Loaded with Ibuprofen for Potential Vaginal Drug Release. [PDF]

Gels
Politrón Zepeda GA, Tinajero-Díaz E, Ilarduya AM, Rodríguez Rodríguez R, Arízaga GGC, Escalera AC, Vasquez Martínez N, Velázquez MM, Carvajal ZYG.   +8 more
europepmc   +1 more source