Results 301 to 310 of about 3,841,835 (347)

Drug Repurposing Using FDA Adverse Event Reporting System (FAERS) Database.

Current Drug Targets
Drug repurposing is an emerging approach to reassigning existing pre-approved therapies for new indications. The FDA Adverse Event Reporting System (FAERS) is a large database of over 28 million adverse event reports submitted by medical providers ...
Robert Morris, Feng Cheng, Rahinatu Ali
semanticscholar   +1 more source

Drug Repurposing Based on Drug–Drug Interaction

Chemical Biology & Drug Design, 2014
Given the high risk and lengthy procedure of traditional drug development, drug repurposing is gaining more and more attention. Although many types of drug information have been used to repurpose drugs, drug–drug interaction data, which imply possible physiological effects or targets of drugs, remain unexploited.
Bin, Zhou, Rong, Wang, Ping, Wu, De-Xin, Kong   +3 more
openaire   +2 more sources

COVID-19: Potential Repurposing Drugs

Infectious Disorders - Drug Targets, 2022
: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the most infectious diseases and caused coronavirus disease in 2019 (COVID-19). It has been widely spread worldwide and infected more than 28 million peoples in 215 countries, and more than 920,000 have now died from COVID-19.
openaire   +2 more sources

Overcoming antibiotic resistance: the potential and pitfalls of drug repurposing

Journal of drug targeting (Print)
Since its emergence shortly after the discovery of penicillin, antibiotic resistance has escalated dramatically, posing a significant health threat and economic burden.
Mohammad Abavisani, Alireza Khoshrou, Souzan Eshaghian, Sercan Karav, A. Sahebkar   +4 more
semanticscholar   +1 more source

Repurposing Drugs for Cancer Prevention

Current Topics in Medicinal Chemistry, 2016
Development of agents for cancer prevention has been particularly challenging for two main reasons. One is the inherent difficulty in identifying targets for the heterogeneous group of processes that lead to invasive cancer arising at different target organ sites, while the other is the need for safe, tolerable interventions that can be given for ...
Daniel K, Lee, Eva, Szabo
openaire   +2 more sources

Drug repurposing in kidney disease

Kidney International, 2018
Drug repurposing, is the re-tasking of known medications for new clinical indications. Advantages, compared to de novo drug development, include reduced cost and time to market plus the added benefit of a known pharmacokinetic and safety profiles. Suitable drug candidates are identified through serendipitous observations, data mining, or increased ...
Usha, Panchapakesan, Carol, Pollock
openaire   +2 more sources

Drug repurposing for cancer

In the dynamic landscape of cancer therapeutics, the innovative strategy of drug repurposing emerges as a transformative paradigm, heralding a new era in the fight against malignancies. This book chapter aims to embark on the comprehension of the strategic deployment of approved drugs for repurposing and the meticulous journey of drug repurposing from ...
Juni, Banerjee, Anand Krishna, Tiwari, Shuvomoy, Banerjee   +2 more
openaire   +2 more sources

Precision Drug Repurposing

Annals of Plastic Surgery
Background Hyperpigmentation is a skin disorder characterized by a localized darkening of the skin due to increased melanin production. When patients fail first line topical treatments, secondary treatments such as chemical peels and lasers are offered ...
Shuwei Chen, Junhao Zeng, Mariam Saad, W. Lineaweaver, Zhiwei Chen, Yuyan Pan   +5 more
semanticscholar   +1 more source

Drug repurposing

2015
The aim of this discussion was to explore the concept and purpose of repositioning drugs, understand the boundaries that still underlie the technique and, analyze repurposed drugs, so they can serve of inspiration for the future of drug discovery and development.
openaire   +1 more source

Drug repurposing: progress, challenges and recommendations

Nature reviews. Drug discovery, 2018
S. Pushpakom, Francesco Iorio, P. Eyers, K. J. Escott, Shirley Hopper, A. Wells, A. Doig, Tim Guilliams, Joanna Latimer, Christina McNamee, A. Norris, P. Sanseau, D. Cavalla, M. Pirmohamed   +13 more
semanticscholar   +1 more source