Results 311 to 320 of about 3,896,424 (394)

Evaluating the Role of Machine Learning and Artificial Intelligence in Oncology Drug Repurposing Efforts. [PDF]

J Res Pharm Pract
Mann A.
europepmc   +1 more source

Repurposing - Finding New Uses for Old (and Patented) Drugs: Bridging the "Valley of Death," to Translate Academic Research Into New Medicines

, 2014
Daniel S. Sem
openalex   +1 more source

Prospects of Inhalable Formulations of Conventionally Administered Repurposed Drugs for Adjunctive Treatment of Drug-Resistant Tuberculosis: Supporting Evidence from Clinical Trials and Cohort Studies

Rajeev Ranjan, Venkata Siva Reddy Devireddy   +1 more
openalex   +2 more sources

Integrative Genomics Reveals Causal Pleiotropy and Therapeutic Opportunities at the Interface of Acute Pancreatitis and Infection

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Understanding the genetic links between acute pancreatitis (AP) and its infectious comorbidities is crucial for prognosis and therapy, yet remains underexplored. Methods We conducted a comprehensive post‐GWAS analysis using large‐scale summary statistics for AP and 16 infectious diseases. To pinpoint pleiotropic genes, we integrated
Bo Zou, Hao Jiang, Jingsheng Ruan, Daifeng Yang, Xing Chen, Shanshan Cai, Xinglin Yi   +6 more
wiley   +1 more source

Transcriptome-Guided Drug Repurposing Identifies Homoharringtonine (HHT) as a Candidate for Radiation-Induced Pulmonary Fibrosis. [PDF]

Pharmaceutics
Farh ME, Kim SY, Park S, Ronglan C, Sohn I, Cho J.   +5 more
europepmc   +1 more source

Artificial intelligence strategies for predicting kinase inhibitor resistance: A comprehensive review of methods, challenges, and future perspectives

Journal of Intelligent Medicine, EarlyView.
Abstract Kinase inhibitors are essential in targeted cancer therapy, yet resistance often emerges through secondary mutations, activation of compensatory signaling pathways, or drug‐efflux mechanisms. Artificial intelligence (AI) provides a workflow‐based strategy rather than a list of unrelated tools for predicting and addressing kinase‐inhibitor ...
Faris Hassan, Mohanad Ali Deifallah, Alaa Zaghloul, Rania Elgohary   +3 more
wiley   +1 more source

Genomics-driven drug repurposing and novel targets identification for sickle cell disease in Saudi patients. [PDF]

Front Bioinform
Alghubayshi A, Alshabeeb MA, Wijesinghe D, AlAwadh M, Alshammari S, Alrajeh K, Alkhairi MA, Islam I, Alaskar A.   +8 more
europepmc   +1 more source

Valproic Acid Inhibits Ferroptosis and Improves Bone Integration in OVX Rats Through the AMPK/SIRT1 Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The prevalence of postmenopausal osteoporosis (PMOP) has been steadily increasing. Ferroptosis has been recognized as a critical factor influencing the bone‐forming ability of bone marrow mesenchymal stem cells (BMSCs). Valproic acid (VPA), an HDAC inhibitor, has been suggested to play a role in regulating osteoporosis development; however ...
Qing‐Song Gu, Yi‐Fan Gu, Jian‐Qiao Li, Yi‐Heng Li, Yu‐Hu Chen, Lin‐Hui Wang, Zi‐Ru Wang, Yi‐Cong Wang, Min Yang   +8 more
wiley   +1 more source

Therapeutic Convergence in Neurodegeneration: Natural Products, Drug Repurposing, and Biomolecular Targets. [PDF]

Biomolecules
Vicidomini C, Roviello GN.
europepmc   +1 more source