Results 341 to 350 of about 3,896,424 (394)

Drug repurposing for Alzheimer’s disease and other neurodegenerative disorders

Nature Communications
Repurposed drugs provide a rich source of potential therapies for Alzheimer’s disease (AD) and other neurodegenerative disorders (NDD). Repurposed drugs have information from non-clinical studies, phase 1 dosing, and safety and tolerability data ...
Jeffrey L. Cummings, Yadi Zhou, Alexandra Van Stone, D. Cammann, R. Tonegawa-Kuji, Jorge Fonseca, Feixiong Cheng   +6 more
semanticscholar   +1 more source

The discovery of novel antivirals for the treatment of mpox: is drug repurposing the answer?

Expert Opinion on Drug Discovery, 2023
Introduction Drugs that have demonstrated good activity against any member of the Orthopoxvirus genus are good candidates for repurposing studies against the mpox virus (MPXV).
Ahmed A. Ezat, J. M. Abduljalil, Ahmed M. Elghareib, A. Samir, Abdo A. Elfiky   +4 more
semanticscholar   +1 more source

Purposeful Drug Repurposing

JAMA Psychiatry
This Viewpoint discusses a proposal to identify candidates for drug repurposing and allocate US Food and Drug Administration funds to cover the cost of evaluating and approving such drugs for their novel indications.
Peter, Nagele, Charles R, Conway, Charles F, Zorumski   +2 more
openaire   +2 more sources

MRNDR: Multihead Attention-Based Recommendation Network for Drug Repurposing

Journal of Chemical Information and Modeling
As is well-known, the process of developing new drugs is extremely expensive, whereas drug repurposing represents a promising approach to augment the efficiency of new drug development.
Xin Feng, Zhansen Ma, Cuinan Yu, Ruihao Xin   +3 more
semanticscholar   +1 more source

Identification of LRRK2 Inhibitors through Computational Drug Repurposing.

ACS Chemical Neuroscience, 2023
Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects more than ten million people worldwide. However, the current PD treatments are still limited and alternative treatment strategies are urgently required.
Shuoyan Tan, Ruiqiang Lu, Dahong Yao, Jun Wang, Peng Gao, Guotong Xie, Huanxiang Liu, X. Yao   +7 more
semanticscholar   +1 more source

Repurposed Drugs

Journal of Prescribing Practice
In this month's article, George Winter discusses the potential for repurposed drugs to change the therapeutic landscape
Duilio Cervantes, Aida Adlimoghaddam
openaire   +2 more sources

Drug Repurposing: A Leading Strategy for New Threats and Targets.

ACS Pharmacology & Translational Science
Less than 6% of rare illnesses have an appropriate treatment option. Repurposed medications for new indications are a cost-effective and time-saving strategy that results in excellent success rates, which may significantly lower the risk associated with ...
Ashish Sriram Mishra, Manimaran Vasanthan, S. P. Malliappan   +2 more
semanticscholar   +1 more source

Drug Repurposing Using FDA Adverse Event Reporting System (FAERS) Database.

Current Drug Targets
Drug repurposing is an emerging approach to reassigning existing pre-approved therapies for new indications. The FDA Adverse Event Reporting System (FAERS) is a large database of over 28 million adverse event reports submitted by medical providers ...
Robert Morris, Feng Cheng, Rahinatu Ali
semanticscholar   +1 more source

Drug Repurposing Based on Drug–Drug Interaction

Chemical Biology & Drug Design, 2014
Given the high risk and lengthy procedure of traditional drug development, drug repurposing is gaining more and more attention. Although many types of drug information have been used to repurpose drugs, drug–drug interaction data, which imply possible physiological effects or targets of drugs, remain unexploited.
Bin, Zhou, Rong, Wang, Ping, Wu, De-Xin, Kong   +3 more
openaire   +2 more sources

COVID-19: Potential Repurposing Drugs

Infectious Disorders - Drug Targets, 2022
: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the most infectious diseases and caused coronavirus disease in 2019 (COVID-19). It has been widely spread worldwide and infected more than 28 million peoples in 215 countries, and more than 920,000 have now died from COVID-19.
openaire   +2 more sources