Results 91 to 100 of about 1,013,456 (328)

Multi-Drug Resistance in Bacterial Genomes—A Comprehensive Bioinformatic Analysis

International Journal of Molecular Sciences, 2023
Antimicrobial resistance is presently one of the greatest threats to public health. The excessive and indiscriminate use of antibiotics imposes a continuous selective pressure that triggers the emergence of multi-drug resistance. We performed a large-scale analysis of closed bacterial genomes to identify multi-drug resistance considering the ResFinder ...
Domingues, Célia P. F., Rebelo, João S., Dionisio, Francisco, Nogueira, Teresa   +3 more
openaire   +3 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Veterinary Medicine Needs New Green Antimicrobial Drugs [PDF]

, 2016
Given that: (1) the worldwide consumption of antimicrobial drugs (AMDs) used in food-producing animals will increase over the coming decades; (2) the prudent use of AMDs will not suffice to stem the rise in human antimicrobial resistance (AMR) of animal ...
Adams, Aidara-Kane, Alvarez, Amidon, Andersson, Andremont, Andremont, Angulo, Ashbolt, Baquero, Bednorz, Bibbal, Bonomo, Brunton, Call, Centers for Disease Control and Prevention, Chantziaras, Chen, Cheng, Cheng, Collignon, DANMAP, de Jong, Dewulf, Duse, Dutil, Edlung, European Food Safety Authority, European Food Safety Authority, European Food Safety Authority, European Medicine Agency, European Medicines Agency, European Medicines Agency, Fairbrother, Food and Drug Administration, Foster, Hansen, Herrick, Heuer, Hofmann, Hojberg, Holman, Horowitz, Huang, Ito, Jacobsen, Kusama, Langlois, Lindecrona, Lipinski, Lipinski, Luo, Marshall, Metz, Midtlyng, Montanari, Naess, Nielsen, Nord, O’Brien, O’Connor, Panagiotidis, Phillips, Pijpers, Pollet, Rashid, Rashid, Ratz, Rioux, Roof, Rose, Sakaeda, Sarmah, Singer, Smith, Sparo, Stamey, Subbiah, Takenouchi, Taverne, Thiele-Bruhn, Tolls, Toutain, Toutain, Toutain, Toutain, Toutain, Trobos, Van Boeckel, van den Bogaard, van der Waaij, Wellington, Whitman, World Health Organisation, World Health Organisation, Yazdankhah, Yusof, Zhang   +97 more
core   +2 more sources

The population genetics of drug resistance evolution in natural populations of viral, bacterial and eukaryotic pathogens

Molecular Ecology, 2015
Drug resistance is a costly consequence of pathogen evolution and a major concern in public health. In this review, we show how population genetics can be used to study the evolution of drug resistance and also how drug resistance evolution is ...
Benjamin A. Wilson, Nandita R. Garud, A. Feder, Z. Assaf, P. Pennings   +4 more
semanticscholar   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Emergence of Herbal Antimicrobial Drug Resistance in Clinical Bacterial Isolates

, 2015
Alternative medicines have been practiced for centuries and remained as integral part of many civilizations around the globe. One important aspect of alternative medicine includes herbal medicines/drugs in which locally available plants or its parts are ...
P. Vadhana, B. Singh, Monika Bharadwaj, S. Singh   +3 more
semanticscholar   +1 more source

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Phage therapy: An alternative to antibiotics in the age of multi-drug resistance. [PDF]

, 2017
The practice of phage therapy, which uses bacterial viruses (phages) to treat bacterial infections, has been around for almost a century. The universal decline in the effectiveness of antibiotics has generated renewed interest in revisiting this practice.
Koskella, Britt, Lin, Derek, Lin, Henry
core   +1 more source

Clinical Implications of Varying Degrees of Vancomycin Susceptilibity in Methicillin-Resistant Staphylococcus aureus Bacteremia

Emerging Infectious Diseases, 2003
We conducted a retrospective study of the clinical aspects of bacteremia caused by methicillin-resistant Staphylococcus aureus (MRSA) with heterogeneously reduced susceptibility to vancomycin.
Mitchell J. Schwaber, Sharon B. Wright, Yehuda Carmeli, Lata Venkataraman, Paola C. DeGirolami, Aneta Gramatikova, Trish M. Perl, George Sakoulas, Howard S. Gold   +8 more
doaj   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source